|Jmol interactive 3D||Image|
|Molar mass||145.25 g·mol−1|
|Density||925 mg mL−1|
|Melting point||22 to 25 °C (72 to 77 °F; 295 to 298 K)|
|145 g L−1 (at 20 °C)|
|UV-vis (λmax)||260 nm|
Refractive index (nD)
|GHS signal word||DANGER|
|P280, P305+351+338, P310|
EU classification (DSD)
|Flash point||112 °C (234 °F; 385 K)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
||This article includes a list of references, but its sources remain unclear because it has insufficient inline citations. (October 2015)|
Polyamines, such as spermidine, are polycationic aliphatic amines and are multifunctional. They serve vital roles in cell survival.
Spermidine synchronizes an array of biological processes (such as Ca2+, Na+, K+ -ATPase) thus maintaining membrane potential and controlling intracellular pH and volume. Spermidine regulates biological processes, such as Ca2+ influx by glutamatergic N-methyl-d-aspartate receptor (NMDA receptor), which has been associated with nitric oxide synthase (NOS) and cGMP/PKG pathway activation and a decrease of Na+,K+-ATPase activity in cerebral cortex synaptosomes.
Spermidine is a longevity agent in mammals due to various mechanisms of action, which are just beginning to be understood. Autophagy is the main mechanism at the molecular level, but evidence has been found for other mechanisms, including inflammation reduction, lipid metabolism, and regulation of cell growth, proliferation and death.
Spermidine is known to regulate plant growth, assisting the in vitro process of transcribing RNA, and inhibition of NOS. Also, spermidine is a precursor to other polyamines, such as spermine and thermospermine, some of which contribute to tolerance against drought and salinity in plants.
Spermidine has been tested and discovered to encourage hair shaft elongation and lengthen hair growth. Spermidine has also been found to “upregulate expression of the epithelial stem cell-associated keratins K15 and K19, and dose-dependently modulated K15 promoter activity in situ and the colony forming efficiency, proliferation and K15 expression of isolated human K15-GFP+ cells in vitro.”
Spermidine's known actions include:
- Inhibits neuronal nitric oxide synthase (nNOS)
- Binds and precipitates DNA
- Polyamine plant growth regulator
Good dietary sources of spermidine are aged cheese, mushrooms, soy products, legumes, corn, and whole grains. In grains, the endosperm contains most of the spermidine. One of the best known grain dietary sources is wheat germ, containing as much as 243 mg/kg.
- Spermidine can be used in electroporation while transferring the DNA into the cell under the electrical impulse. May be used for purification of DNA-binding proteins.
- Spermidine is also used, along with calcium chloride, for precipitating DNA onto microprojectiles for bombardment with a gene gun.
- Spermidine has also been found to reduce the amount of aging in yeast, flies, worms, and human immune cells by inducing autophagy. Recently Tirupathi Pichiah et al., suggested that spermidine may be helpful for treating type 2 diabetes.
- American Heritage Dictionary Retrieved 2014-11-18.
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- Ali, Mohamed Atiya; Poortvliet, Eric; Strömberg, Roger; Yngve, Agneta (2011). "Polyamines in foods: development of a food database". Food Nutr Res. 55: 5572. doi:10.3402/fnr.v55i0.5572. PMID 21249159.
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- T.M. Klein, T. Gradziel, M.E. Fromm, J.C. Sanford (1988). "Factors influencing gene delivery into Zea mays cells by high–velocity microprojectiles,". Nature Biotechnology 6 (5): 559–63. doi:10.1038/nbt0588-559.
- Tobias Eisenberg, Heide Knauer, Alexandra Schauer, Sabrina Büttner, Christoph Ruckenstuhl, Didac Carmona-Gutierrez, Julia Ring, Sabrina Schroeder, Christoph Magnes, Lucia Antonacci, Heike Fussi, Luiza Deszcz, Regina Hart, Elisabeth Schraml, Alfredo Criollo, Evgenia Megalou, Daniela Weiskopf, Peter Laun, Gino Heeren, Michael Breitenbach, Beatrix Grubeck-Loebenstein, Eva Herker, Birthe Fahrenkrog, Kai-Uwe Fröhlich, Frank Sinner, Nektarios Tavernarakis, Nadege Minois, Guido Kroemer, Frank Madeo (4 October 2009). "Induction of autophagy by spermidine promotes longevity,". Nature Cell Biology 11 (11): 1305–14. doi:10.1038/ncb1975. PMID 19801973.
- Tirupathi Pichiah, PB; Suriyakalaa, U; Kamalakkannan, S; Kokilavani, P; Kalaiselvi, S; SankarGanesh, D; Gowri, J; Archunan, G; Cha, YS; Achiraman, S (October 2011). "Spermidine may decrease ER stress in pancreatic beta cells and may reduce apoptosis via activating AMPK dependent autophagy pathway". Medical hypotheses 77 (4): 677–9. doi:10.1016/j.mehy.2011.07.014. PMID 21831529.