Sphincter of Oddi

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sphincter of Oddi
Interior of the descending portion of the duodenum, showing bile papilla.
Latin m. sphincter ampullae
MeSH A03.
TA A05.8.02.018
FMA 15077
Anatomical terminology

The sphincter of Oddi (or hepatopancreatic sphincter) is a muscular valve that controls the flow of digestive juices (bile and pancreatic juice) through the ampulla of Vater into the second part of the duodenum. It is named after Ruggero Oddi.[1] The sphincter of Oddi is relaxed by the hormone cholecystokinin (CCK)[2] via vasoactive intestinal peptide (VIP).[3]

Clinical significance[edit]

Opiates can cause spasms of the sphincter of Oddi, leading to increased serum amylase levels.


  1. ^ synd/2709 at Who Named It?
  2. ^ Board Review Series (5th ed.). Lippincott Williams & Wilkins medical. March 2006. p. 220. ISBN 978-0781798761. 
  3. ^ Wiley, J W; O'Dorisio, T M; Owyang, C (1988). "Vasoactive intestinal polypeptide mediates cholecystokinin-induced relaxation of the sphincter of Oddi". Journal of Clinical Investigation 81 (6): 1920–4. doi:10.1172/JCI113539. PMC 442644. PMID 3384954. 
  • Gray's Anatomy, 39th ed. p. 1228.

Further reading[edit]