Edney's collaboration with Queen included mostly keyboards (his main instrument), plus rhythm guitar and backing vocals. Accompanying the band on its tours since 1984, he was also part of Roger Taylor's side project The Cross as well as Brian May's band when they toured in 1993 and 1998.
After the death of Freddie Mercury, (who was also Queen's primary or main pianist), Edney took over Mercury's role on piano during Queen + Paul Rodgers 2005, 2006 and 2008 tours, playing all piano parts on a Korg Triton keyboard, in addition to all other keyboard parts. During the 2005–06 tour, he was often referred to as "The Wizard" by Roger Taylor. He returned as keyboardist for the Queen + Adam Lambert tours in 2012, 2014, and 2015. He has also been the keyboardist for the London production of We Will Rock You since it opened in 2002.
Edney is also the musical director of the official Queen tribute band, the Queen Extravaganza.