The digital-like uniformity of action potentials is contradicted by experimental data. Electrophysiologists have observed that the shape of recorded action potentials changes in time. Recent experimental evidence has shown that action potentials in neurons are subject to waveform modulation while they travel down axons or dendrites. The action potential waveform can be modulated by neuron geometry, local alterations in the ion conductance, and other biophysical properties including neurotransmitter release.
- Aur D., Connolly C.I., Jog M.S., (2005) Computing spike directivity with tetrodes, Journal of Neuroscience Methods, 149 (1), pp. 57–63.
- Sasaki, T., Matsuki, N., Ikegaya, Y. 2011 Action-potential modulation during axonal conduction. Science 331 (6017), pp. 599–601.