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AMI-193 structure.png
Systematic (IUPAC) name
CAS Registry Number 510-74-7
ATC code None
PubChem CID: 68186
UNII 471LF4O004 YesY
ChEBI CHEBI:64207 YesY
Chemical data
Formula C22H27FN3O2
Molecular mass 384.466 g/mol
 YesY (what is this?)  (verify)

Spiramide (AMI-193) is a selective 5-HT2A, 5-HT1A, and D2 receptor antagonist. It has negligible affinity for the 5-HT2C receptor.[1][2][3]


  1. ^ Czoty PW, Howell LL (October 2000). "Behavioral effects of AMI-193, a 5-HT(2A)- and dopamine D(2)-receptor antagonist, in the squirrel monkey". Pharmacology, Biochemistry, and Behavior 67 (2): 257–64. doi:10.1016/S0091-3057(00)00321-X. PMID 11124389. 
  2. ^ Luparini MR, Garrone B, Pazzagli M, Pinza M, Pepeu G (November 2004). "A cortical GABA-5HT interaction in the mechanism of action of the antidepressant trazodone". Progress in Neuro-psychopharmacology & Biological Psychiatry 28 (7): 1117–27. doi:10.1016/j.pnpbp.2004.05.046. PMID 15610924. 
  3. ^ Hamada K, Yoshida M, Isayama H, Yagi Y, Kanazashi S, Kashihara Y, Takeuchi K, Yamaguchi I (November 2007). "Possible involvement of endogenous 5-HT in aggravation of cerulein-induced acute pancreatitis in mice". Journal of Pharmacological Sciences 105 (3): 240–50. doi:10.1254/jphs.FP0071049. PMID 17965538.