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Spongiosis is mainly intercellular[1] edema (abnormal accumulation of fluid) in the epidermis,[2] and is characteristic of eczematous dermatitis, manifested clinically by intraepidermal vesicles (fluid-containing spaces), "juicy" papules, and/or lichenification.[3]

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  1. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. Chapter: Clinical and Pathologic Differential Diagnosis. ISBN 1-4160-2999-0. 
  2. ^ Kumar, Vinay; Fausto, Nelso; Abbas, Abul (2004) Robbins & Cotran Pathologic Basis of Disease (7th ed.). Saunders. Page 1230. ISBN 0-7216-0187-1.
  3. ^ Marks, James G; Miller, Jeffery (2006). Lookingbill and Marks' Principles of Dermatology (4th ed.). Elsevier Inc. Page 28. ISBN 1-4160-3185-5.