Spontaneous coronary artery dissection
|Spontaneous coronary artery dissection|
|Other names||Coronary artery dissection|
Spontaneous coronary artery dissection (SCAD) is a rare but dangerous condition in which one of the coronary arteries that supply the heart spontaneously develops a tear, with a separation and weakening of the walls of the artery.
SCAD is a major cause of heart attacks in young, otherwise healthy women without known risk factors. While the exact cause is not yet known, SCAD is likely related to changes that occur during and after pregnancy, as well as other diseases. These changes lead to the dissection of the wall which restricts blood flow to the heart and causes symptoms. SCAD is often diagnosed in the cath lab with angiography, though more advanced confirmatory tests exist. While the risk of death due to SCAD is low, it has a relatively high rate of recurrence leading to further heart attack-like symptoms in the future. It was first described in 1931.
Signs and symptoms
SCAD often presents as chest pain, like a heart attack, in young to middle-aged, healthy women. This pattern may also include rapid heartbeat, shortness of breath, sweating, extreme tiredness, nausea, and dizziness.
A minority of people with SCAD may also present in cardiogenic shock (2-5%), ventricular arrhythmias (3-11%), or after sudden cardiac death Pregnancy- and postpartum-associated SCAD generally have worse outcomes compared to other cases.
Risk factors include pregnancy and the postpartum period. There is evidence to suggest that a major cause of spontaneous coronary artery dissection is related to estrogen- and progesterone-related vascular changes affecting the coronary arteries. Some case reports and case series suggest associations with autoimmune inflammatory diseases, but there have not been larger studies to explore this relationship. Underlying heritable conditions such as fibromuscular dysplasia and connective-tissue disorders (e.g., Marfan syndrome, Ehlers-Danlos syndrome, and Loeys-Dietz syndrome) are associated with SCAD, but SCAD otherwise lacks a significant genetic component. SCAD triggers may include severe physical or emotional stress, but many cases have no obvious cause.
SCAD symptoms are the result of a restriction in the size of the affected coronary artery. The dissection leads to a collection of blood, or hematoma, between the layers of the artery wall. The presence of this hematoma in the wall of the artery restricts blood flow through the inside, or lumen, of the blood vessel. This restriction limits the availability of oxygen and nutrients to the heart myocardium, leading to heart attack symptoms. As yet, there is no consensus on why the hematoma develops in the first place.
Given the demographics of SCAD, it is important to maintain a high index of suspicion for the condition in otherwise low-risk women presenting with symptoms of acute coronary syndrome. Initial evaluation may show ECG changes of ST elevation, like heart attacks due to other causes. SCAD comprises 1-4% of all cases of acute coronary syndrome.
With typically elevated cardiac biomarkers and ECG changes, people will often undergo coronary angiography evaluation. It is important to recognize SCAD through angiography as other confirmatory measures carry increased risks.
Angiographic appearances of SCAD fall into three categories. Type 1 lesions appear as classic angiographic dissections, with a false lumen distinct from the true lumen. These are the easiest to identify as SCAD clinically, though relatively uncommon. Type 2 lesions - the most common subtype of SCAD - appear as a long, smooth narrowing of the vessel without a distinctly visible false and true lumen. Type 3 lesions appear similar to atherosclerotic lesions and are difficult to confirm as SCAD through angiography alone, possibly requiring the use of intracoronary imaging.
Intracoronary imaging (ICI), consisting of intracoronary optical coherence tomography (OCT) and intravascular ultrasound (IVUS) can help distinguish SCAD from atherosclerotic disease when it is difficult to do so with angiography. ICI techniques provide a direct view of the walls of the coronary artery to confirm SCAD, but may actually worsen the dissection as the probes are inserted into the damaged area. ICI confers a 3.4% risk of iatrogenic dissection in people with SCAD compared to 0.2% risk in the general population. Between the two ICI methods, OCT - a relatively newer technique - has superior spatial resolution than IVUS and is the preferred technique if ICI is required, but the need to inject additional contrast with OCT poses risk for worsening the dissection. Coronary CT angiography has been proposed as a method of evaluating SCAD in lower-risk people with research into the approach ongoing.
Management of SCAD is varied depending upon the presenting symptoms. In most people who are hemodynamically stable without high-risk coronary involvement, conservative medical management, which can control blood pressure, is recommended. In these people, especially if angiography demonstrates adequate coronary flow, the most likely course usually leads to spontaneous healing, often within 30 days.
In cases involving high-risk coronaries, hemodynamic instability, or a lack of improvement or worsening after initial attempts at treatment, urgent treatment with coronary stents or coronary artery bypass surgery may be necessary. Stents carry the risk of worsening the dissection or have an increased risk of other complications as the vessel walls in SCAD are already weak due to the disease prior to introducing the stent. Large studies into coronary artery bypass surgery are lacking, but this approach is typically used to redirect blood to the heart around the affected area for cases involving the left main coronary artery or when other approaches fail.
After addressing the SCAD, people are often treated with typical post-heart attack care, though people who are pregnant may require altered therapy due to the possibility of some teratogenic cardiac medications affecting fetal development. Depending on the clinical situation, providers may screen for associated connective tissue diseases.
People with SCAD have a low in-hospital mortality after treatment. However, the lesion may worsen after leaving the hospital within the first month. One study suggested a 1.2% mortality rate following SCAD but a 19.9% risk for either death, heart attacks, or strokes. Even afterwards, SCAD has a relatively high recurrence risk at 30% within 10 years, often at a different site than the initial lesion - meaning that stents placed in the location of the first lesion may not protect against a second. Given the lack of consensus on the cause of SCAD, prevention of future SCAD may include medical therapy, counseling about becoming pregnant again (for those who had pregnancy-associated SCAD), or avoidance of oral contraceptives - as they contain estrogen and progesterone.
Spontaneous coronary artery dissection was first described in the year 1931, at postmortem examination, in a 42 year old woman.
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