Spore photoproduct lyase

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Spore photoproduct lyase
EC number
CAS number 37290-70-3
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Spore photoproduct lyase (EC, SAM, SP lyase, SPL, SplB, SplG) is a radical SAM enzyme that repairs a particular kind of lesion that arises upon UV-radiation of bacterial DNA. This repair mechanism is one of the reasons for the resilience of certain bacterial spores. Through a series of radical reactions the photodimer, 3 5-thyminyl-5,6-dihydrothymine, is disconnected to give back two functional thymine rings.[1][2]

Spore photoproduct lyase (reaction diagram).png


  1. ^ Susan C. Wang; Perry A. Frey (2007). "S-adenosylmethionine as an oxidant: the radical SAM superfamily". Trends in Biochemical Sciences. 32 (3): 101–10. doi:10.1016/j.tibs.2007.01.002. PMID 17291766. Note that the SPL drawings are incorrect in this paper and the erratum
  2. ^ Jeffrey M. Buis; Jennifer Cheek; Efthalia Kalliri; Joan B. Broderick (2006). "Characterization of an Active Spore Photoproduct Lyase, a DNA Repair Enzyme in the Radical S-Adenosylmethionine Superfamily". Journal of Biological Chemistry. 281 (36): 25994–26003. doi:10.1074/jbc.M603931200. PMID 16829680. 

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