The Springfield-Branson, Missouri Combined Metropolitan Area, as defined by the United States Census Bureau, is an area consisting of seven counties in southwestern Missouri, anchored by the city of Springfield - the state's third largest city. Other primary population centers in the metro area include Branson, Nixa, Ozark, Republic, Marshfield, Bolivar, and Willard. Currently, the city limits of Springfield reach the Ozark City limits at the Christian County line on US 65, the city limits of Republic at James River Freeway on the southwest side of the city, and the Strafford city limits on Route 744 on the northeast side of the city. As of the 2010 census, the MSA had a population of 520,589, though the 2014 Estimates place the population at 537,631.
U.S. Route 60 - a four-lane divided highway from Republic to James River Freeway and from US 65 to east of Rogersville, becomes part of James River Freeway on the south side of Springfield
U.S. Route 65 - a freeway (officially the Schoolcraft Freeway in Springfield proper-6 lanes). A four-lane highway from Buffalo to the Arkansas state line.
U.S. Route 160 a two-lane highway between Willard and Springfield, joins James River Freeway on the southwest side of Springfield, becomes a four-lane divided highway at Campbell Avenue to Nixa
Route 13 - connects Springfield with Kansas City, becomes Kansas Expressway in Springfield, then joins James River Freeway to Campbell Avenue, and joins US 160 through Nixa
Route 14 - a two-lane highway which connects Ozark and Nixa
Route 125 - a two-lane highway between Strafford and Rogersville. It mainly lies in the rural part of the metropolitan area.
Route 360 - a section of James River Freeway from US 60 to I-44 west of Springfield
Route 413 - a four-lane highway joined with US 60 from Republic to James River Freeway, continues north and east into Springfield as Sunshine Street
Route 744 - Known as Kearney Street in Springfield. It is a four lane highway that stretches from the Sprinfield-Branson National Airport to I-44. It lies on the north side of Springfield.
Historic U.S. Route 66 passes through the Springfield area. It enters the area through Strafford, and follows Kearney Street, Glenstone Avenue, St. Louis Street, College Street, and Chestnut Expressway in Springfield. It continues west down Route 266 west of Springfield.