SRA1

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SRA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSRA1, SRA, SRAP, STRAA1, pp7684, steroid receptor RNA activator 1
External IDsMGI: 1344414 HomoloGene: 11906 GeneCards: SRA1
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for SRA1
Genomic location for SRA1
Band5q31.3Start140,537,340 bp[1]
End140,558,252 bp[1]
RNA expression pattern
PBB GE SRA1 gnf1h06172 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001035235
NM_001253764

NM_001164406
NM_025291

RefSeq (protein)

NP_001030312
NP_001240693

NP_001157878
NP_079567

Location (UCSC)Chr 5: 140.54 – 140.56 MbChr 18: 36.67 – 36.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Steroid receptor RNA activator 1 also known as steroid receptor RNA activator protein (SRAP) is a protein that in humans is encoded by the SRA1 gene.[5][6] The mRNA transcribed from the SRA1 gene is a component of the ribonucleoprotein complex containing NCOA1. This functional RNA also encodes a protein.[7]

Function[edit]

This gene is involved in transcriptional coactivation by steroid receptor. There is currently data suggesting this gene encodes both a non-coding RNA that functions as part of a ribonucleoprotein complex and a protein coding mRNA. Increased expression of both the transcript and the protein is associated with cancer.[6]

Interactions[edit]

SRA1 has been shown to interact with:

The SRAP has been shown to interact with its SRA RNA counterpart indirectly with the functional sub-structure STR7 of SRA RNA.[10] Originally proposed to be RRM containing, SRAP has been demonstrated to have a helix bundle at its C-terminal end while N-terminal to this domain appears unstructured.[11]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000213523 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006050 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Lanz RB, McKenna NJ, Onate SA, Albrecht U, Wong J, Tsai SY, Tsai MJ, O'Malley BW (April 1999). "A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex". Cell. 97 (1): 17–27. doi:10.1016/S0092-8674(00)80711-4. PMID 10199399.
  6. ^ a b "Entrez Gene: SRA1 steroid receptor RNA activator 1".
  7. ^ Chooniedass-Kothari S, Emberley E, Hamedani MK, Troup S, Wang X, Czosnek A, Hube F, Mutawe M, Watson PH, Leygue E (May 2004). "The steroid receptor RNA activator is the first functional RNA encoding a protein". FEBS Letters. 566 (1–3): 43–7. doi:10.1016/j.febslet.2004.03.104. PMID 15147866.
  8. ^ a b c Watanabe M, Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S (March 2001). "A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA". The EMBO Journal. 20 (6): 1341–52. doi:10.1093/emboj/20.6.1341. PMC 145523. PMID 11250900.
  9. ^ Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M, Evans RM (May 2001). "Sharp, an inducible cofactor that integrates nuclear receptor repression and activation". Genes & Development. 15 (9): 1140–51. doi:10.1101/gad.871201. PMC 312688. PMID 11331609.
  10. ^ Hubé F, Velasco G, Rollin J, Furling D, Francastel C (January 2011). "Steroid receptor RNA activator protein binds to and counteracts SRA RNA-mediated activation of MyoD and muscle differentiation". Nucleic Acids Research. 39 (2): 513–25. doi:10.1093/nar/gkq833. PMC 3025577. PMID 20855289.
  11. ^ Bilinovich SM, Davis CM, Morris DL, Ray LA, Prokop JW, Buchan GJ, Leeper TC (April 2014). "The C-terminal domain of SRA1p has a fold more similar to PRP18 than to an RRM and does not directly bind to the SRA1 RNA STR7 region". Journal of Molecular Biology. 426 (8): 1753–65. doi:10.1016/j.jmb.2014.01.007. PMID 24486611.

Further reading[edit]

External links[edit]