The parish was founded in 1911 and built by immigrants from southern Italy using plans supplied by architect Anthony J. DePace. It was named after the Sicilian Saint Vito (St. Vitus). To this day the parish still maintains a large percentage of Italian-American parishioners. There are monthly devotions to Padre Pio every 4th Thursday at 7:30 p.m. The parish also holds an annual Festa Italiana in honor of its patron saint. 
St. Vito's Parish School operated from 1960 to 1986 and was staffed by the Dominican Sisters of Sparkill. The church was heavily damaged in the flood that ravaged the Village of Mamaroneck in April 2007. The church has since been restored.