Drayton was born on March 11, 1971, in Cleveland, Ohio. He attended Allegheny College, where he played running back on the football team. As a sophomore, Drayton helped lead the Gators to the 1990 NCAA Division III national championship, and ended his career as the top rusher in Division III history (record later broken). He also competed in track and field, winning numerous NCAC titles, and earned all-conference honors in both sports. Drayton is married to Monique Fuller and has two children.
Drayton held running back coaching positions with the Eastern Michigan Eagles (1994), Penn Quakers (1995), Villanova Wildcats (1996–1999), and Bowling Green Falcons (2000), before being hired by the Green Bay Packers as Assistant Offensive Quality Control & Special Teams Coach from 2001–2003.
Following his time with the Packers he worked as a Running Backs Coach with the Mississippi State Bulldogs (2004), Florida Gators (2005–2007, 2010), Tennessee Volunteers (2008), and Syracuse Orange (2009). He returned to the Gators for the 2010 campaign.
In January 2011, Drayton was hired as a Wide Receivers Coach by the Ohio State Buckeyes. Following the 2011 season, he was reassigned to the role of Running Backs Coach, under new head coach Urban Meyer (his former boss and mentor at Florida).
In February 2015, Drayton was hired as a Running Backs coach for the Chicago Bears.