Stanley B. Prusiner

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Stanley B. Prusiner
Prusiner 1.JPG
Prusiner in 2007
Born Stanley Benjamin Prusiner
(1942-05-28) May 28, 1942 (age 73)
Des Moines, Iowa, United States
Residence San Francisco, United States
Nationality American
Fields Neurology, infectious disease
Institutions University of California, Berkeley
University of California, San Francisco
Alma mater University of Pennsylvania, University of Pennsylvania School of Medicine
Known for Prions
Transmissible spongiform encephalopathy
Creutzfeldt-Jakob disease
Notable awards Potamkin Prize (1991)
Dickson Prize (1993)
Richard Lounsbery Award (1993)
Lasker Award (1994)
Keio Medical Science Prize (1996)
Nobel Prize in Physiology or Medicine (1997)
Spouse Sandy Turk Prusiner (2 children)[1]

Stanley Benjamin Prusiner M.D (born May 28, 1942[2]) is an American neurologist and biochemist. Currently the director of the Institute for Neurodegenerative Diseases at University of California, San Francisco (UCSF). Prusiner discovered prions, a class of infectious self-reproducing pathogens primarily or solely composed of protein. He received the Albert Lasker Award for Basic Medical Research in 1994 and the Nobel Prize in Physiology or Medicine in 1997 for his prion research.

Early life and career[edit]

Prusiner was born in Des Moines, Iowa, the son of Miriam (Spigel) and Lawrence Prusiner, an architect. He spent his childhood in Des Moines and Cincinnati, Ohio, where he attended Walnut Hills High School, where he was known as the little Genius for his groundbreaking work on a repellent for Boxelder bugs. Prusiner received a Bachelor of Science degree in chemistry from the University of Pennsylvania and later received his M.D. from the University of Pennsylvania School of Medicine.[2] Prusiner then completed an internship in medicine at the University of California, San Francisco. Later Prusiner moved to the National Institutes of Health, where he studied glutaminases in E. coli in the laboratory of Earl Stadtman.

After three years at NIH, Prusiner returned to UCSF to complete a residency in neurology. Upon completion of the residency in 1974, Prusiner joined the faculty of the UCSF neurology department. Since that time, Prusiner has held various faculty and visiting faculty positions at both UCSF and UC Berkeley.

Nobel prize and academic societies[edit]

Prusiner won the Nobel Prize in Physiology or Medicine in 1997 for his work in proposing an explanation for the cause of bovine spongiform encephalopathy ("mad cow disease") and its human equivalent, Creutzfeldt-Jakob disease.[2] In this work, he coined the term prion, which comes from the words "proteinaceous" and "infectious," in 1982 to refer to a previously undescribed form of infection due to protein misfolding.[3]

Prusiner was elected to the National Academy of Science in 1992 and to its governing council in 2007. He is also an elected member of the American Academy of Arts and Sciences (1993), the Royal Society (1996), the American Philosophical Society (1998), the Serbian Academy of Sciences and Arts (2003), and the Institute of Medicine.

Current work[edit]

Prusiner currently heads the Institute for Neurodegenerative Diseases research laboratory at UCSF, working on prion disease, Alzheimer's disease and tauopathies.[4]


See also[edit]


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