State Highway 52 (abbreviated SH-52) is two once-connected highways in the U.S. state of Oklahoma. There are no lettered spur routes from either of them.
The southern SH-52 is a short, 4.06 miles (6.53 km) state highway in McIntosh County, Oklahoma. It connects State Highway 9 to the town of Hanna.
The northern SH-52 runs for 16.46 miles (26.49 km) from US-266 northeast of Grayson to SH-16. Along the way it intersects US-62 near Morris.
At one time, at least as recently as 1972, the two sections of SH-52 were connected by a dirt section running from SH-9 to US-266. This section has since been decommissioned. 
The entire route is in McIntosh County.
The entire route is in Okmulgee County.