Stephania is a genus of flowering plants in the family Menispermaceae, native to eastern and southern Asia and Australasia. They are herbaceous perennial vines growing to around four metres tall, with a large, woody caudex. The leaves are arranged spirally on the stem, and are peltate, with the leaf petiole attached near the centre of the leaf. The name Stephania comes from the Greek, "a crown". This refers to the anthers being arranged in a crown like manner.
One species, S. tetrandra, is among the 50 fundamental herbs used in traditional Chinese medicine, where it is called han fang ji (漢防己, "Chinese fang ji"). Other plants named fang ji are sometimes substituted for it. Other varieties substituted include Cocculus thunbergii, C. trulobus, Aristolochia fanchi, Stephania tetrandria, and Sinomenium acutun. Notable among these is guang fang ji (廣防己, "(GuangDong,GuangXi) fang ji", Aristolochia fanchi. Because of its toxicity, it is used in TCM only with great caution.
There is evidence that a few species of Stephania are toxic. However, the most commonly available species in the United States, Stephania tetrandra, has not been shown to be toxic. Any confusion regarding the possible toxicity of Stephania tetrandra was entirely due to an inadvertent shipment of Aristolochia fangchi sent in its stead to a Belgian clinic in 1993. The errant batch of Aristolochia was later confirmed via phytochemical analysis.
Chemical investigation of Stephania rotunda Lour. growing in Vietnam in 2005 led to the isolation and structural elucidation of three new alkaloids, 5-hydroxy-6,7-dimethoxy-3,4-dihydroisoquinolin-1(2H)-one, thaicanine 4-O-beta-D-glucoside, as well as (−)-thaicanine N-oxide (4-hydroxycorynoxidine), along with 23 known alkaloids.
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- GRIN. "GRIN Species Records of genus Stephania". Taxonomy for Plants. National Germplasm Resources Laboratory, Beltsville, Maryland: USDA, ARS, National Genetic Resources Program. Retrieved September 29, 2013.
-  Journal of Ethnopharmacology 132 (2010). p. 380
- Nunez, Kelvin R. (2006). Trends in Kidney Cancer Research. 18. Hauppauge, New York: Nova Science Publishers. p. 78. ISBN 1-59454-141-8.
- Thuy, T. T; Porzel, A.; Franke, K.; Wessjohann, L.; Sung, T. V. (September 2005). "Isoquinolone and protoberberine alkaloids from Stephania rotunda". Die Pharmazie. 60 (9): 701–704. PMID 16222872.
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