Stefanos Stefanopoulos (Greek: Στέφανος Στεφανόπουλος, 3 July 1898, Pyrgos, Elis – 4 October 1982, Athens) was a Greek politician, and served as Prime Minister of Greece from 1965 to 1966.
He was a moderate conservative, and served as a cabinet member during Alexandros Papagos' government. He even served as acting Prime Minister for a day after the latter's death on 4 October 1955.
On 17 September 1965, he became Prime Minister of Greece during the period of the "Apostasia", supported by conservatives and defecting members of the Centre Union party. Unable to gain a parliamentary vote of confidence, his government fell on 22 December 1966.