Stephen Oliver (scientist)

From Wikipedia, the free encyclopedia
Jump to: navigation, search
For other people of the same name, see Stephen Oliver.
Steve Oliver
Born Stephen George Oliver
(1949-11-03) 3 November 1949 (age 65) [1]
Institutions
Alma mater University of Bristol
Thesis The role of RNA in the maintenance of mitochondrial DNA in the yeast, Saccharomyces cerevisiae. (1975)
Doctoral students
Known for
Notable awards
Website
www.bioc.cam.ac.uk/uto/oliver
www.wolfson.cam.ac.uk/people/professor-stephen-oliver

Stephen George Oliver FMedSci FAAAS (born 3 November 1949) is a Professor in the Department of Biochemistry at the University of Cambridge,[13] director of the Cambridge Systems Biology Centre[14] and a Fellow of Wolfson College, Cambridge.[2][15]

Education[edit]

Oliver was educated at the University of Bristol gaining a Bachelor of Science degree in Microbiology in 1971 followed by a PhD from the National Institute for Medical Research (NIMR) in 1974.[16]

Research[edit]

Oliver's areas of research include functional genomics, systems biology[17][18][19][20][21] and drug discovery[22][23][24][25][26][27] using the model organism Saccharomyces cerevisiae[28] which he has worked on since the 1970s.[29] In 1992, whilst working at UMIST, Oliver led the team which provided first complete sequence analysis of an entire chromosome from any organism.[30] More recently he has also been involved in the creation of a Robot Scientist[12][31] and has been awarded research funding as principal investigator or co-investigator with a total value of over £26 million by the Biotechnology and Biological Sciences Research Council.[32]

References[edit]

  1. ^ a b c OLIVER, Prof. Stephen George. Who's Who 2014 (online edition via Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc.  (subscription required)
  2. ^ a b "Professor Steve Oliver | Wolfson College Cambridge". Archived from the original on 2013-01-04. 
  3. ^ Cornell, M.; Paton, N. W.; Oliver, S. G. (2004). "A critical and Integrated View of the Yeast Interactome". Comparative and Functional Genomics 5 (5): 382–402. doi:10.1002/cfg.412. PMC 2447467. PMID 18629175. 
  4. ^ Oliver, S. (1977). "On the mutability of the yeast mitochondrial genome". Journal of Theoretical Biology 67 (2): 195–201. doi:10.1016/0022-5193(77)90193-X. PMID 330960. 
  5. ^ Yen, Kuangyu (2007). Experimental and bioinformatic analyses of the functional equivalence between yeast and human genes in protein secretion (PhD thesis). University of Manchester. [dead link]
  6. ^ Yen, K.; Gitsham, P.; Wishart, J.; Oliver, S. G.; Zhang, N. (2003). "An improved tetO promoter replacement system for regulating the expression of yeast genes". Yeast 20 (15): 1255–1262. doi:10.1002/yea.1037. PMID 14618563. 
  7. ^ Harrison, Richard (2008). Exploring environmentally-dependent genetic variation in the yeast Saccharomyces cerevisiae (PhD thesis). University of Manchester. [dead link]
  8. ^ Harrison, R.; Papp, B.; Pal, C.; Oliver, S. G.; Delneri, D. (2007). "Plasticity of genetic interactions in metabolic networks of yeast". Proceedings of the National Academy of Sciences 104 (7): 2307–2312. doi:10.1073/pnas.0607153104. PMC 1892960. PMID 17284612. 
  9. ^ Lockwood, Christopher Robert (2008). Can gains and losses of transcription factor binding sites be related to what occurs elsewhere in the regulatory region? (PhD thesis). University of Manchester. [dead link]
  10. ^ Omara, Walid Ahmed Mohamed (2009). Towards production and delivery of HPV16-L1 vaccine using genetically modified yeast (PhD thesis). University of Manchester. [dead link]
  11. ^ Omara, W. A. M.; Rash, B. M.; Hayes, A.; Wickham, M. S. J.; Oliver, S. G.; Stateva, L. I. (2010). "Conditional cell-wall mutants of Saccharomyces cerevisiae as delivery vehicles for therapeutic agents in vivo to the GI tract". Journal of Biotechnology 147 (2): 136–143. doi:10.1016/j.jbiotec.2010.03.010. PMID 20356564. 
  12. ^ a b King, R. D.; Whelan, K. E.; Jones, F. M.; Reiser, P. G. K.; Bryant, C. H.; Muggleton, S. H.; Kell, D. B.; Oliver, S. G. (2004). "Functional genomic hypothesis generation and experimentation by a robot scientist". Nature 427 (6971): 247–252. doi:10.1038/nature02236. PMID 14724639. 
  13. ^ http://www.bioc.cam.ac.uk/uto/oliver.html Research in the Department of Biochemistry
  14. ^ "Steve Oliver — Cambridge Systems Biology Centre". Archived from the original on 2013-01-04. 
  15. ^ Stephen Oliver's publications indexed by the Scopus bibliographic database, a service provided by Elsevier.
  16. ^ Oliver, Stephen (1975). The role of RNA in the maintenance of mitochondrial DNA in the yeast, Saccharomyces cerevisiae (PhD thesis). Council for National Academic Awards. 
  17. ^ List of publications from Microsoft Academic Search
  18. ^ Von Mering, C.; Krause, R.; Snel, B.; Cornell, M.; Oliver, S.; Fields, S.; Bork, P. (2002). "Comparative assessment of large-scale data sets of protein-protein interactions". Nature 417 (6887): 399–403. doi:10.1038/nature750. PMID 12000970. 
  19. ^ Goffeau, A.; Barrell, B. G.; Bussey, H.; Davis, R. W.; Dujon, B.; Feldmann, H.; Galibert, F.; Hoheisel, J. D.; Jacq, C.; Johnston, M.; Louis, E. J.; Mewes, H. W.; Murakami, Y.; Philippsen, P.; Tettelin, H.; Oliver, S. G. (1996). "Life with 6000 Genes". Science 274 (5287): 546, 563–7. doi:10.1126/science.274.5287.546. PMID 8849441. 
  20. ^ Oliver, S. G.; Teusink, L. M.; Broadhurst, B.; Zhang, D.; Hayes, N.; Walsh, A.; Berden, M. C.; Brindle, J. A.; Kell, K. M.; Rowland, D. B.; Westerhoff, J. J.; Van Dam, H. V.; Oliver, K. (2001). "A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations". Nature Biotechnology 19 (1): 45–50. doi:10.1038/83496. PMID 11135551. 
  21. ^ http://www.biomedexperts.com/Profile.bme/1052747/Stephen_G_Oliver Steve Oliver profile in BiomedExperts
  22. ^ Kell, D. B.; Dobson, P. D.; Bilsland, E.; Oliver, S. G. (2012). "The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: What we (need to) know and how we can do so". Drug Discovery Today 18 (5–6): 218–39. doi:10.1016/j.drudis.2012.11.008. PMID 23207804. 
  23. ^ Lanthaler, K.; Bilsland, E.; Dobson, P. D.; Moss, H. J.; Pir, P. N.; Kell, D. B.; Oliver, S. G. (2011). "Genome-wide assessment of the carriers involved in the cellular uptake of drugs: A model system in yeast". BMC Biology 9: 70. doi:10.1186/1741-7007-9-70. PMC 3280192. PMID 22023736. 
  24. ^ Kell, D. B.; Dobson, P. D.; Oliver, S. G. (2011). "Pharmaceutical drug transport: The issues and the implications that it is essentially carrier-mediated only". Drug Discovery Today 16 (15–16): 704–714. doi:10.1016/j.drudis.2011.05.010. PMID 21624498. 
  25. ^ Dobson, P. D.; Smallbone, K.; Jameson, D.; Simeonidis, E.; Lanthaler, K.; Pir, P.; Lu, C.; Swainston, N.; Dunn, W. B.; Fisher, P.; Hull, D.; Brown, M.; Oshota, O.; Stanford, N. J.; Kell, D. B.; King, R. D.; Oliver, S. G.; Stevens, R. D.; Mendes, P. (2010). "Further developments towards a genome-scale metabolic model of yeast". BMC Systems Biology 4: 145. doi:10.1186/1752-0509-4-145. PMC 2988745. PMID 21029416. 
  26. ^ Dobson, P. D.; Lanthaler, K.; Oliver, S. G.; Kell, D. B. (2009). "Implications of the dominant role of transporters in drug uptake by cells". Current topics in medicinal chemistry 9 (2): 163–181. doi:10.2174/156802609787521616. PMID 19200003. 
  27. ^ Herrgård, M. J.; Swainston, N.; Dobson, P.; Dunn, W. B.; Arga, K. Y. I.; Arvas, M.; Blüthgen, N.; Borger, S.; Costenoble, R.; Heinemann, M.; Hucka, M.; Le Novère, N.; Li, P.; Liebermeister, W.; Mo, M. L.; Oliveira, A. P.; Petranovic, D.; Pettifer, S.; Simeonidis, E.; Smallbone, K.; Spasić, I.; Weichart, D.; Brent, R.; Broomhead, D. S.; Westerhoff, H. V.; Kirdar, B. L.; Penttilä, M.; Klipp, E.; Palsson, B. Ø.; Sauer, U.; Oliver, S.G.; Mendes, P.; Nielsen, J.; Kell, D.B. (2008). "A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology". Nature Biotechnology 26 (10): 1155–1160. doi:10.1038/nbt1492. PMC 4018421. PMID 18846089. 
  28. ^ Von Mering, C.; Krause, R.; Snel, B.; Cornell, M.; Oliver, S.; Fields, S.; Bork, P. (2002). "Comparative assessment of large-scale data sets of protein-protein interactions". Nature 417 (6887): 399–403. doi:10.1038/nature750. PMID 12000970. 
  29. ^ Oliver, S. G.; Williamson, D. H. (1976). "The molecular events involved in the induction of petite yeast mutants by fluorinated pyrimidines". MGG Molecular & General Genetics 146 (3): 253–259. doi:10.1007/BF00701248. 
  30. ^ Oliver, S. G.; Van Der Aart, Q. J. M.; Agostoni-Carbone, M. L.; Aigle, M.; Alberghina, L.; Alexandraki, D.; Antoine, G.; Anwar, R.; Ballesta, J. P. G.; Benit, P.; Berben, G.; Bergantino, E.; Biteau, N.; Bolle, P. A.; Bolotin-Fukuhara, M.; Brown, A.; Brown, A. J. P.; Buhler, J. M.; Carcano, C.; Carignani, G.; Cederberg, H.; Chanet, R.; Contreras, R.; Crouzet, M.; Daignan-Fornier, B.; Defoor, E.; Delgado, M.; Demolder, J.; Doira, C.; Dubois, E. (1992). "The complete DNA sequence of yeast chromosome III". Nature 357 (6373): 38–46. doi:10.1038/357038a0. PMID 1574125. 
  31. ^ King, P.; Rowland, J.; Aubrey, W.; Liakata, M.; Markham, M.; Soldatova, L. N.; Whelan, K. E.; Clare, A.; Young, M.; Sparkes, A.; Oliver, S. G.; Pir, P. (2009). "The Robot Scientist Adam". Computer 42 (7): 46–54. doi:10.1109/MC.2009.270. 
  32. ^ "UK Government Grants awarded to Stephen Oliver". Retrieved 2014-07-04.