Stephen Oliver (scientist)

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search

Steve Oliver
Born Stephen George Oliver
(1949-11-03) 3 November 1949 (age 68) [1]
Alma mater University of Bristol
Known for
Scientific career
Thesis The role of RNA in the maintenance of mitochondrial DNA in the yeast, Saccharomyces cerevisiae. (1975)

Stephen George Oliver FMedSci FAAAS (born 3 November 1949) is a Professor in the Department of Biochemistry at the University of Cambridge,[6] director of the Cambridge Systems Biology Centre[7] and a Fellow of Wolfson College, Cambridge.[3][8]


Oliver was educated at the University of Bristol gaining a Bachelor of Science degree in Microbiology in 1971 followed by a PhD from the National Institute for Medical Research (NIMR) in 1974.[9]


Oliver's areas of research include functional genomics, systems biology[10][11][12][13][14] and drug discovery[15][16][17][18][19][20] using the model organism Saccharomyces cerevisiae[21] which he has worked on since the 1970s.[22] In 1992, whilst working at UMIST, Oliver led the team which provided first complete sequence analysis of an entire chromosome from any organism.[23] More recently he has also been involved in the creation of a Robot Scientist[2][24] and has been awarded research funding as principal investigator or co-investigator with a total value of over £26 million by the Biotechnology and Biological Sciences Research Council.[25]


  1. ^ a b c OLIVER, Prof. Stephen George. Who's Who. 2014 (online edition via Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc.  closed access publication – behind paywall (subscription required)
  2. ^ a b King, R. D.; Whelan, K. E.; Jones, F. M.; Reiser, P. G. K.; Bryant, C. H.; Muggleton, S. H.; Kell, D. B.; Oliver, S. G. (2004). "robot scientist". Nature. 427 (6971): 247–252. doi:10.1038/nature02236. PMID 14724639. 
  3. ^ a b "Professor Steve Oliver | Wolfson College Cambridge". Archived from the original on 4 January 2013. 
  4. ^ Cornell, M.; Paton, N. W.; Oliver, S. G. (2004). "A critical and Integrated View of the Yeast Interactome". Comparative and Functional Genomics. 5 (5): 382–402. doi:10.1002/cfg.412. PMC 2447467Freely accessible. PMID 18629175. 
  5. ^ Oliver, S. (1977). "On the mutability of the yeast mitochondrial genome". Journal of Theoretical Biology. 67 (2): 195–201. doi:10.1016/0022-5193(77)90193-X. PMID 330960. 
  6. ^ Research in the Department of Biochemistry
  7. ^ "Steve Oliver — Cambridge Systems Biology Centre". Archived from the original on 4 January 2013. 
  8. ^ Stephen Oliver's publications indexed by the Scopus bibliographic database, a service provided by Elsevier. (subscription required)
  9. ^ Oliver, Stephen (1975). The role of RNA in the maintenance of mitochondrial DNA in the yeast, Saccharomyces cerevisiae (PhD thesis). Council for National Academic Awards. 
  10. ^ List of publications from Microsoft Academic
  11. ^ Von Mering, C.; Krause, R.; Snel, B.; Cornell, M.; Oliver, S.; Fields, S.; Bork, P. (2002). "Comparative assessment of large-scale data sets of protein-protein interactions". Nature. 417 (6887): 399–403. doi:10.1038/nature750. PMID 12000970. 
  12. ^ Goffeau, A.; Barrell, B. G.; Bussey, H.; Davis, R. W.; Dujon, B.; Feldmann, H.; Galibert, F.; Hoheisel, J. D.; Jacq, C.; Johnston, M.; Louis, E. J.; Mewes, H. W.; Murakami, Y.; Philippsen, P.; Tettelin, H.; Oliver, S. G. (1996). "Life with 6000 Genes". Science. 274 (5287): 546, 563–7. doi:10.1126/science.274.5287.546. PMID 8849441. 
  13. ^ Oliver, S. G.; Teusink, L. M.; Broadhurst, B.; Zhang, D.; Hayes, N.; Walsh, A.; Berden, M. C.; Brindle, J. A.; Kell, K. M.; Rowland, D. B.; Westerhoff, J. J.; Van Dam, H. V.; Oliver, K. (2001). "A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations". Nature Biotechnology. 19 (1): 45–50. doi:10.1038/83496. PMID 11135551. 
  14. ^ "Archived copy". Archived from the original on 21 March 2012. Retrieved 28 May 2011.  Steve Oliver profile in BiomedExperts
  15. ^ Kell, D. B.; Dobson, P. D.; Bilsland, E.; Oliver, S. G. (2012). "The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: What we (need to) know and how we can do so". Drug Discovery Today. 18 (5–6): 218–39. doi:10.1016/j.drudis.2012.11.008. PMID 23207804. 
  16. ^ Lanthaler, K.; Bilsland, E.; Dobson, P. D.; Moss, H. J.; Pir, P. N.; Kell, D. B.; Oliver, S. G. (2011). "Genome-wide assessment of the carriers involved in the cellular uptake of drugs: A model system in yeast". BMC Biology. 9: 70. doi:10.1186/1741-7007-9-70. PMC 3280192Freely accessible. PMID 22023736. 
  17. ^ Kell, D. B.; Dobson, P. D.; Oliver, S. G. (2011). "Pharmaceutical drug transport: The issues and the implications that it is essentially carrier-mediated only". Drug Discovery Today. 16 (15–16): 704–714. doi:10.1016/j.drudis.2011.05.010. PMID 21624498. 
  18. ^ Dobson, P. D.; Smallbone, K.; Jameson, D.; Simeonidis, E.; Lanthaler, K.; Pir, P.; Lu, C.; Swainston, N.; Dunn, W. B.; Fisher, P.; Hull, D.; Brown, M.; Oshota, O.; Stanford, N. J.; Kell, D. B.; King, R. D.; Oliver, S. G.; Stevens, R. D.; Mendes, P. (2010). "Further developments towards a genome-scale metabolic model of yeast". BMC Systems Biology. 4: 145. doi:10.1186/1752-0509-4-145. PMC 2988745Freely accessible. PMID 21029416. 
  19. ^ Dobson, P. D.; Lanthaler, K.; Oliver, S. G.; Kell, D. B. (2009). "Implications of the dominant role of transporters in drug uptake by cells". Current topics in medicinal chemistry. 9 (2): 163–181. doi:10.2174/156802609787521616. PMID 19200003. 
  20. ^ Herrgård, M. J.; Swainston, N.; Dobson, P.; Dunn, W. B.; Arga, K. Y. I.; Arvas, M.; Blüthgen, N.; Borger, S.; Costenoble, R.; Heinemann, M.; Hucka, M.; Le Novère, N.; Li, P.; Liebermeister, W.; Mo, M. L.; Oliveira, A. P.; Petranovic, D.; Pettifer, S.; Simeonidis, E.; Smallbone, K.; Spasić, I.; Weichart, D.; Brent, R.; Broomhead, D. S.; Westerhoff, H. V.; Kirdar, B. L.; Penttilä, M.; Klipp, E.; Palsson, B. Ø.; Sauer, U.; Oliver, S.G.; Mendes, P.; Nielsen, J.; Kell, D.B. (2008). "A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology". Nature Biotechnology. 26 (10): 1155–1160. doi:10.1038/nbt1492. PMC 4018421Freely accessible. PMID 18846089. 
  21. ^ Von Mering, C.; Krause, R.; Snel, B.; Cornell, M.; Oliver, S.; Fields, S.; Bork, P. (2002). "Comparative assessment of large-scale data sets of protein-protein interactions". Nature. 417 (6887): 399–403. doi:10.1038/nature750. PMID 12000970. 
  22. ^ Oliver, S. G.; Williamson, D. H. (1976). "The molecular events involved in the induction of petite yeast mutants by fluorinated pyrimidines". MGG Molecular & General Genetics. 146 (3): 253–259. doi:10.1007/BF00701248. 
  23. ^ Oliver, S. G.; Van Der Aart, Q. J. M.; Agostoni-Carbone, M. L.; Aigle, M.; Alberghina, L.; Alexandraki, D.; Antoine, G.; Anwar, R.; Ballesta, J. P. G.; Benit, P.; Berben, G.; Bergantino, E.; Biteau, N.; Bolle, P. A.; Bolotin-Fukuhara, M.; Brown, A.; Brown, A. J. P.; Buhler, J. M.; Carcano, C.; Carignani, G.; Cederberg, H.; Chanet, R.; Contreras, R.; Crouzet, M.; Daignan-Fornier, B.; Defoor, E.; Delgado, M.; Demolder, J.; Doira, C.; Dubois, E. (1992). "The complete DNA sequence of yeast chromosome III". Nature. 357 (6373): 38–46. doi:10.1038/357038a0. PMID 1574125. 
  24. ^ King, P.; Rowland, J.; Aubrey, W.; Liakata, M.; Markham, M.; Soldatova, L. N.; Whelan, K. E.; Clare, A.; Young, M.; Sparkes, A.; Oliver, S. G.; Pir, P. (2009). "The Robot Scientist Adam". Computer. 42 (7): 46–54. doi:10.1109/MC.2009.270. 
  25. ^ "UK Government Grants awarded to Stephen Oliver". Retrieved 2014-07-04.