Sterol regulatory element-binding protein 2

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Protein SREBF2 PDB 1ukl.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesSREBF2, SREBP-2, SREBP2, bHLHd2, sterol regulatory element binding transcription factor 2
External IDsOMIM: 600481 MGI: 107585 HomoloGene: 20966 GeneCards: SREBF2
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for SREBF2
Genomic location for SREBF2
Band22q13.2Start41,833,079 bp[1]
End41,907,307 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 22: 41.83 – 41.91 MbChr 15: 82.15 – 82.21 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 (SREBF2) is a protein that in humans is encoded by the SREBF2 gene.[5]


This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix leucine zipper (bHLH-Zip) domain.[6] Various single nucleotide polymorphisms (SNPs) of the SREBF2 have been identified and some of them are found to be associated with higher risk of knee osteoarthritis. [7]


SREBF2 has been shown to interact with INSIG1[8][9] and CREB-binding protein.[10]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198911 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022463 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hua X, Yokoyama C, Wu J, Briggs MR, Brown MS, Goldstein JL, Wang X (Dec 1993). "SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element". Proceedings of the National Academy of Sciences of the United States of America. 90 (24): 11603–7. Bibcode:1993PNAS...9011603H. doi:10.1073/pnas.90.24.11603. PMC 48032. PMID 7903453.
  6. ^ "Entrez Gene: SREBF2 sterol regulatory element binding transcription factor 2".
  7. ^ Qiu XM, Jin CT, Wang W (Apr 2014). "Association between single nucleotide polymorphisms of sterol regulatory element binding protein-2 gene and risk of knee osteoarthritis in a Chinese Han population". The Journal of International Medical Research. 42 (2): 320–8. doi:10.1177/0300060513507392. PMID 24496149.
  8. ^ Dobrosotskaya IY, Goldstein JL, Brown MS, Rawson RB (Sep 2003). "Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs". The Journal of Biological Chemistry. 278 (37): 35837–43. doi:10.1074/jbc.M306476200. PMID 12842885.
  9. ^ Yang T, Espenshade PJ, Wright ME, Yabe D, Gong Y, Aebersold R, Goldstein JL, Brown MS (Aug 2002). "Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER". Cell. 110 (4): 489–500. doi:10.1016/S0092-8674(02)00872-3. PMID 12202038.
  10. ^ Oliner JD, Andresen JM, Hansen SK, Zhou S, Tjian R (Nov 1996). "SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein". Genes & Development. 10 (22): 2903–11. doi:10.1101/gad.10.22.2903. PMID 8918891.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.