Streptococcus sanguinis

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Streptococcus sanguinis
Scientific classification
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: S. sanguinis
Binomial name
Streptococcus sanguinis
White and Niven 1946

Streptococcus sanguinis, formerly known as Streptococcus sanguis, is a Gram-positive facultative anaerobic[1] coccus species of bacteria and a member of the Viridans Streptococcus group. S. sanguinis is a normal inhabitant of the healthy human mouth where it is particularly found in dental plaque, where it modifies the environment to make it less hospitable for other strains of Streptococcus that cause cavities, such as Streptococcus mutans.


S. sanguinis may gain entrance to the bloodstream when opportunity presents (dental cleanings and surgeries) and colonize the heart valves, particularly the mitral and aortic valves, where it is the most common cause of subacute bacterial endocarditis. For this reason, oral surgeons often prescribe a short course of antibiotics to be taken a few days before to a few days after oral surgery. Once an infection has occurred, treatment is much more complicated and generally involves the administration of several weeks of penicillin and aminoglycoside antibiotics. Moxifloxacin is a quinolone antibiotic, prescribed for bacterial infections such as pneumonia, bronchitis, sinus, skin and skin structure infections, and others. It works by stopping the growth of bacteria.[2]


The complete genomic sequence of S. sanguinis was determined in 2007 by laboratories at Virginia Commonwealth University.[3]


  1. ^ 10.1128/IAI.73.9.6064-6074.2005
  2. ^ Moxifloxacin
  3. ^ Xu, Ping; Alves JM, Kitten T, Brown A, Chen Z, Ozaki LS, Manque P, Ge X, Serrano MG, Puiu D, Hendricks S, Wang Y, Chaplin MD, Akan D, Paik S, Peterson DL, Macrina FL, Buck GA (Apr 2007). "Genome of the opportunistic pathogen Streptococcus sanguinis". J Bacteriol 189 (8): 3166–75. doi:10.1128/JB.01808-06. PMC 1855836. PMID 17277061. 

Further reading[edit]

  • Morita, Chisato; Sumioka, Ryuichi; Nakata, Masanobu; Okahashi, Nobuo; Wada, Satoshi; Yamashiro, Takashi; Hayashi, Mikako; Hamada, Shigeyuki; Sumitomo, Tomoko; Kawabata, Shigetada (Aug 1, 2014). "Cell Wall-Anchored Nuclease of Streptococcus sanguinis Contributes to Escape from Neutrophil Extracellular Trap-Mediated Bacteriocidal Activity". PLoS ONE 9 (8): e103125. doi:10.1371/journal.pone.0103125. 

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