Streptococcus thermophilus

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Streptococcus thermophilus
20101210 020132 StreptococcusThermophilus.jpg
Scientific classification
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: S. thermophilus
Binomial name
Streptococcus thermophilus
(ex Orla-Jensen 1919)
Schleifer et al. 1995

Streptococcus salivarius subsp. thermophilus (Orla-Jensen, 1919) Farrow et Collins 1984

Streptococcus salivarius subsp. thermophilus (previous name Streptococcus thermophilus )[1][2] is a Gram-positive bacterium and a homofermentative facultative anaerobe, of the viridans group.[3] It tests negative for cytochrome, oxidase, and catalase, and positive for alpha-hemolytic activity.[3] It is not motile and does not form endospores.[3]

It is also classified as a lactic acid bacterium.[4] S. thermophilus is found in fermented milk products, and is generally used in the production of yogurt,[5] alongside Lactobacillus delbrueckii subsp. bulgaricus. The two species are synergistic, and S. thermophilus probably provides L. d. bulgaricus with folic acid and formic acid which it uses for purine synthesis.[6]


S. thermophilus is one of the most widely used bacteria in the dairy industry. USDA statistics from 1998 showed that more than 1.02 billion kilograms of mozzarella cheese and 621 million kilograms of yogurt were produced from S. thermophilus.[7] Although its genus, Streptococcus, includes some pathogenic species, food industries consider S. thermophilus a safer bacterium than many other Streptococcus species. In fact, yogurt and cheese that contain live cultures of S. thermophilus are thought to be beneficial to health.[8] Live cultures of S. thermophilus make it easier for people who are lactose intolerant to digest dairy products. The bacteria break down lactose, the sugar in milk, that lactose-intolerant people find difficult to digest.

Yogurt production[edit]

As early as the 1900s, S. thermophilus has been used to make yogurt. Its purpose is to turn lactose, the sugar in milk, into lactic acid. The increase in lactic acid turns milk into the gel-like structure characteristic of yogurt.[9]


"Streptococcus" derives from a Greek term meaning "twisted berry" and refers to the way the bacterium is grouped in chains that resemble a string of beads.[10] "Thermophilus" derives from the Greek thermē, meaning "heat". It refers to an organism's ability to thrive at high temperatures.[11]


Pathogenic potential[edit]

The genus Streptococcus includes several pathogenic species, such as S. pneumoniae and S. pyogenes, but food industries consider S. thermophilus non-pathogenic. S. thermophilus is believed to have developed separately from pathogenic Streptococcus species for at least 3000 years. Research teams have sequenced the genome of two strains of S. thermophilus, CNRZ1066 and LMG13811, and stated that the bacteria are not dangerous.[12]

When the S. thermophilus species diverged from its pathogenic relatives, it lost most of the genes acknowledged as being responsible for virulence. The species may have lost these genes because it adapted to a new, dairy-producing, environment in which it did not need these genes anymore.

Genome analysis has also shown that by adapting to dairy production, the species has acquired genes that its pathogenic cousins do not have. For example, S. thermophilus can use the energy in lactose to help itself grow.

Reduced-fat cheese[edit]

S. thermophilus helps make reduced-fat cheese with similar characteristics to regular, full-fat cheese. In the experiment, two different strains of bacteria are used to make reduced-fat cheddar cheese: a strain of Lactococcus lactis and a strain of S. thermophilus. These bacteria are chosen because they produce exopolysaccharide (EPS) which give reduced-fat cheese a similar texture and flavor as regular cheese. However, cheese made from L. lactis yielded a different type of cheese from S. thermophilus.

L. lactis produced cheese with higher moisture levels compared to other reduced-fat cheeses. On the other hand, S. thermophilus produced low moisture cheese and decreased the bitterness of cheese. It had been concluded that applying both L. lactis and S. thermophilus strains create higher quality reduced-fat cheese with similar characteristics to regular cheese.[13]


Chemotherapy often causes mucositis, severe inflammation of primarily the small intestines. Currently, there is no treatment to alleviate the symptoms of mucositis caused by chemotherapy. When rats were inflicted with mucositis by chemotherapy drugs, the intestinal tissues in those pretreated with streptococcus thermophilus TH-4 functioned more healthily and were less distressed.[14]

In her nutrition book, Food: Your Miracle Medicine, Jean Carper describes an experiment by Dr. Joseph A. Scimeca, in which commercially-available yogurt containing S. thermophilus and L. d. bulgaricus was fed to mice. After these mice were injected with cancer cells, the incidence of lung cancer in the yogurt-fed mice was one-third less than expected.[15]

Growth rate in children[edit]

S. thermophilus supplements have maintained a stable growth rate in children. Children who received S. thermophilus supplements had better growth during a 6-month period than children who did not receive the supplement.[16]

Antibiotic-associated diarrhea[edit]

Strains of S. thermophilus have also reduced risks of AAD (antibiotic-associated diarrhea), an issue that results from taking antibiotics. Antibiotics can have the adverse effect of destroying beneficial bacteria and causing harmful bacteria to multiply, which invokes diarrhea. Adults who ate yogurt containing S. thermophilus while being treated with antibiotics had lower rates of diarrhea than the control group (12.4% vs. 23.7%).[17]


  1. ^ Tannock, Gerald W., ed. (2005). Probiotics And Prebiotics: Scientific Aspects. Caister Academic Press. p. 43. ISBN 1-904455-01-8. Retrieved 2014-03-31. 
  2. ^ "Validation of the Publication of New Names and New Combinations Previously Effectively Published Outside the IJSB: List No. 54". International Journal of Systematic Bacteriology 45 (3): 619–620. July 1995. doi:10.1099/00207713-45-3-619. 
  3. ^ a b c European Bioinformatics Institute: Bacteria Genomes – Streptococcus Thermophilus
  4. ^ Courtin, P.; Rul, F. O. (2003). "Interactions between microorganisms in a simple ecosystem: yogurt bacteria as a study model". Le Lait 84: 125–134. doi:10.1051/lait:2003031. 
  5. ^ Kiliç, AO; Pavlova, SI; Ma, WG; Tao, L (1996). "Analysis of Lactobacillus phages and bacteriocins in American dairy products and characterization of a phage isolated from yogurt". Applied and environmental microbiology 62 (6): 2111–6. PMC 167989. PMID 8787408. 
  6. ^ Sieuwerts, S.; Molenaar, D.; Van Hijum, S. A. F. T.; Beerthuyzen, M.; Stevens, M. J. A.; Janssen, P. W. M.; Ingham, C. J.; De Bok, F. A. M.; De Vos, W. M.; Van Hylckama Vlieg, J. E. T. (2010). "Mixed-Culture Transcriptome Analysis Reveals the Molecular Basis of Mixed-Culture Growth in Streptococcus thermophilus and Lactobacillus bulgaricus". Applied and Environmental Microbiology 76 (23): 7775–7784. doi:10.1128/AEM.01122-10. PMC 2988612. PMID 20889781. 
  7. ^ Hutkins, Robert. "Streptococcus Thermophilus LMD-9". JGI Microbes (2002).
  8. ^ Taylor, John R. and Mitchell, Deborah. The Wonder of Probiotics. New York, NY: St. Martin’s Press, 2007.
  9. ^ Delcour, J., T. Ferain, and P. Hols. "Advances in the Genetics of Thermophilic Lactic Acid Bacteria". Food Biotechnology 11 (2000): 497–504.
  10. ^ "Streptococcus." Encyclopædia Britannica. Encyclopædia Britannica Online. 13 April 2011.
  11. ^ "Thermophile." Encyclopædia Britannica. Encyclopædia Britannica Online. Encyclopædia Britannica, 2011. Web. 24 Apr. 2011. [1]
  12. ^ "Streptococcus Thermophilus: A Bacterium Which Is Harmless to Health." International Research Associates. 14 Nov. 2006. Web. 25 Apr. 2011.
  13. ^ Awad S, AN Hassan and K Muthukumarappan. "Application of Exopolysaccharide-Producing Cultures in Reduced-Fat Cheddar Cheese." Journal of Dairy Science 88 (2005): 4204–4213.
  14. ^ Whitford, E. J.; Cummins, A. G.; Butler, R. N.; Prisciandaro, L. D.; Fauser, J. K.; Yazbeck, R; Lawrence, A; Cheah, K. Y.; Wright, T. H.; Lymn, K. A.; Howarth, G. S. (2009). "Effects of Streptococcus thermophilus TH-4 on intestinal mucositis induced by the chemotherapeutic agent, 5-Fluorouracil (5-FU)". Cancer biology & therapy 8 (6): 505–11. doi:10.4161/cbt.8.6.7594. PMID 19305160. 
  15. ^ Carper, Jean. Food: Your Miracle Medicine. New York, NY: Harper Collins Publishers, 1994
  16. ^ Nopchinda, S et al. "Effect of Bifidobacterium Bb12 with or without Streptococcus Thermophilus Supplemented Formula on Nutritional Status." J. Medical Association of Thailand 85 (2002): 1225–1231.
  17. ^ Ripudaman S. Beniwal; Vincent C. Arena; Leno Thomas; Sudhir Narla; Thomas F. Imperiale; Rauf A. Chaudhry; Usman A. Ahmad (2003). "A Randomized Trial of Yogurt for Prevention of Antibiotic-Associated Diarrhea". Digestive Diseases and Sciences 48 (10): 2077–2082. doi:10.1023/A:1026155328638. PMID 14627358.