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Streptolysin is a streptococcal hemolytic exotoxin.[1][2]

Types include streptolysin O (SLO), which is oxygen-labile, and streptolysin S (SLS), which is oxygen-stable.[3]

An antibody, antistreptolysin O, can be detected in an antistreptolysin O titre.

Streptolysin O is hemolytically active only in a reversibly reduced state, unlike streptolysin S, which is stable in the presence of oxygen. Another difference is that SLO is antigenic, while SLS is not antigenic due to its small size.


  1. ^ "streptolysin" at Dorland's Medical Dictionary
  2. ^ Streptolysin at the US National Library of Medicine Medical Subject Headings (MeSH)
  3. ^ Sierig G, Cywes C, Wessels MR, Ashbaugh CD (January 2003). "Cytotoxic effects of streptolysin o and streptolysin s enhance the virulence of poorly encapsulated group a streptococci". Infect. Immun. 71 (1): 446–55. doi:10.1128/IAI.71.1.446-455.2003. PMC 143243. PMID 12496195.