Streptomyces coelicolor

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Streptomyces coelicolor
Scientific classification
Domain: Bacteria
Phylum: Actinobacteria
Order: Actinomycetales
Family: Streptomycetaceae
Genus: Streptomyces
Species: S. coelicolor
Binomial name
Streptomyces coelicolor

Streptomyces coelicolor is a soil-dwelling Gram-positive bacterium that belongs to the genus Streptomyces.[1]


The genome of one strain of S. coelicolor was sequenced in 2002.[2] It contains 8,667,507 bp, encoding 7,825 predicted genes, including over 20 gene clusters for the synthesis of known or predicted natural products.

Usage in biotechnology[edit]

Strains of S. coelicolor produce various antibiotics, including actinorhodin, methylenomycin, undecylprodigiosin,[3] and perimycin.[4][5] Certain strains of S. coelicolor can be used for heterologous protein expression.[1]


  1. ^ a b "Streptomyces coelicolor". John Innes Center. Retrieved 25 January 2010. 
  2. ^ Bentley SD, Chater KF, Cerdeño-Tárraga AM, et al. (May 2002). "Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)". Nature 417 (6885): 141–7. doi:10.1038/417141a. PMID 12000953. 
  3. ^ Brian P, Riggle PJ, Santos RA, Champness WC (June 1996). "Global negative regulation of Streptomyces coelicolor antibiotic synthesis mediated by an absA-encoded putative signal transduction system". J. Bacteriol. 178 (11): 3221–31. PMC 178074. PMID 8655502. 
  4. ^ Liu CM, McDaniel LE, Schaffner CP (March 1972). "Fungimycin, biogenesis of its aromatic moiety". The Journal of Antibiotics 25 (3): 187–8. doi:10.7164/antibiotics.25.187. PMID 5034814. 
  5. ^ Lee CH, Schaffner CP (May 1969). "Perimycin. The structure of some degradation products". Tetrahedron 25 (10): 2229–32. doi:10.1016/S0040-4020(01)82770-8. PMID 5788396. 

Further reading[edit]

  • Galet, Justine; Deveau, Aurélie; Hôtel, Laurence; Leblond, Pierre; Frey‐Klett, Pascale; Aigle, Bertrand (September 2014). "Gluconic acid‐producing Pseudomonas sp. prevent γ‐actinorhodin biosynthesis by Streptomyces coelicolor A3(2)". Archives of Microbiology 196 (9): 619–627. doi:10.1007/s00203-014-1000-4. 

External links[edit]