Streptomyces hygroscopicus

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Streptomyces hygroscopicus
Streptomyces hygroscopicus.JPG
Streptomyces hygroscopicus colonies
Scientific classification
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Actinomycetales
Family: Streptomycetaceae
Genus: Streptomyces
Species: S. hygroscopicus
Binomial name
Streptomyces hygroscopicus
(Jensen 1931) Yüntsen et al. 1956 [1]
Subspecies

S. hygroscopicus angustmyceticus
S. hygroscopicus decoyicus
S. hygroscopicus glebosus
S. hygroscopicus hygroscopicus
S. hygroscopicus ossamyceticus

Synonyms

Actinomyces hygroscopicus Jensen 1931[2]

Streptomyces hygroscopicus is a bacterial species in the genus Streptomyces. It was first described by Hans Laurits Jensen in 1931.[3]

Biochemistry[edit]

Cultures of different strains of S. hygroscopicus can be used to produce a number of chemical compounds or enzymes.

Small molecules[edit]

Immunosuppressants[edit]

Sirolimus (also known as rapamycin) is an immunosuppressant that has been isolated from S. hygroscopicus from soil samples from Easter Island.[4] Ascomycin can be used to treat autoimmune diseases and skin diseases, and can help prevent rejection after an organ transplant.

Antibiotics[edit]

The antibiotics geldanamycin, hygromycin B, nigericin, validamycin, and cyclothiazomycin are found in S. hygroscopicus.

Experimental cancer drugs[edit]

Indolocarbazoles can be found in S. hygroscopicus .

Anthelmintics and insecticides[edit]

Milbemycin and milbemycin oxime can be found in S. hygroscopicus cultures.

Herbicide[edit]

S. hygroscopicus also produces the natural herbicide bialaphos.[5]

Enzymes[edit]

The enzymes alpha,alpha-trehalose-phosphate synthase (GDP-forming), carboxyvinyl-carboxyphosphonate phosphorylmutase and hygromycin-B kinase can be isolated from cultures of S. hygroscopicus.

References[edit]

  1. ^ Page Streptomyces file 2 (File 2: Streptomyces felleus - Streptomyces mutomycini) on Bacterio.net. Retrieved 12th December 2015
  2. ^ Streptomyces hygroscopicus on biocyc.org
  3. ^ Jensen, HL (1931). "Contributions to our knowledge of the Actinomycetales. II. The definition and subdivision of the genus Actinomyces, with a preliminary account of Australian soil Actinomycetes". Proceedings of The Linnean Society of New South Wales. 56: 345–370. 
  4. ^ Vézina C, Kudelski A, Sehgal SN (October 1975). "Rapamycin (AY-22,989), a new antifungal antibiotic". J. Antibiot. 28 (10): 721–6. doi:10.7164/antibiotics.28.721. PMID 1102508. 
  5. ^ Murakami, Takeshi; Anzai, Hiroyuki; Imai, Satoshi; Satoh, Atsuyuki; Nagaoka, Kozo; Thompson, Charles J. (October 1986). "The bialaphos biosynthetic genes of Streptomyces hygroscopicus: Molecular cloning and characterization of the gene cluster". MGG Molecular & General Genetics. 205 (1): 42–53. doi:10.1007/BF02428031. 

External links[edit]