Stromal vascular fraction

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Stromal vascular fraction
Stromal Vascular Fraction
Stromal Vascular Fraction

Stromal vascular fraction (SVF) of adipose tissue is a source of preadipocytes, mesenchymal stem cells (MSC), endothelial progenitor cell, T cells, B cells, mast cells as well as adipose tissue macrophages.[1][2]


Stromal Vascular Fraction (SVF) is a component of the lipoaspirate obtained from liposuction of excess adipose tissue. Lipoaspirate, the waste product of liposuction (cosmetic surgery), contains a large population of regenerative cells called adipose derived regenerative cells (ADRCs), which share a number of similarities with bone marrow cells, including the capacity for multilineage differentiation. Autologous SVFs containing ADRCs are currently being used in clinical settings for various orthopedic applications for human patients without any serious side effects.[3][4][5]


  1. ^ Riordan, Neil H; Ichim, Thomas E; Min, Wei-Ping; Wang, Hao; Solano, Fabio; Lara, Fabian; Alfaro, Miguel; Rodriguez, Jorge; Harman, Robert J; Patel, Amit N; Murphy, Michael P; Lee, Roland R; Minev, Boris (2009). "Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis". Journal of Translational Medicine. 7: 29. doi:10.1186/1479-5876-7-29. PMC 2679713Freely accessible. PMID 19393041. 
  2. ^ Schipper, Henk S; Prakken, Berent; Kalkhoven, Eric; Boes, Marianne (2012). "Adipose tissue-resident immune cells: Key players in immunometabolism". Trends in Endocrinology & Metabolism. 23 (8): 407–15. doi:10.1016/j.tem.2012.05.011. PMID 22795937. 
  3. ^ Pak, Jaewoo; Lee, Jung Hun; Park, Kwang Seung; Park, Moonhee; Kang, Lin-Woo; Lee, Sang Hee (2017). "Current use of autologous adipose tissue-derived stromal vascular fraction cells for orthopedic applications". Journal of Biomedical Science. 24 (1): 9. doi:10.1186/s12929-017-0318-z. PMC 5282826Freely accessible. PMID 28143470. 
  4. ^ Pak, Jaewoo; Lee, Jung Hun; Park, Kwang Seung; Jeon, Jeong Ho; Lee, Sang Hee (2017). "Potential use of mesenchymal stem cells in human meniscal repair: Current insights". Open Access Journal of Sports Medicine. 8: 33–38. doi:10.2147/OAJSM.S113018. PMC 5367609Freely accessible. PMID 28356779. 
  5. ^ Zhang, Jinxin; Du, Chunyan; Guo, Weimin; Li, Pan; Liu, Shuyun; Yuan, Zhiguo; Yang, Jianhua; Sun, Xun; Yin, Heyong; Guo, Quanyi; Zhou, Chenfu (2017). "Adipose Tissue-Derived Pericytes for Cartilage Tissue Engineering". Current Stem Cell Research & Therapy. 12 (6): 513–21. doi:10.2174/1574888X12666170321111211. PMID 28325151.