The term "strong inference" was coined by John R. Platt, a biophysicist at the University of Chicago. Platt notes that some fields, such as molecular biology and high-energy physics, seem to adhere strongly to strong inference, with very beneficial results for the rate of progress in those fields.
The single hypothesis problem
|“||The moment one has offered an original explanation for a phenomenon which seems satisfactory, that moment affection for [one’s] intellectual child springs into existence, and as the explanation grows into a definite theory [one’s] parental affections cluster about [the] offspring and it grows more and more dear .... There springs up also unwittingly a pressing of the theory to make it fit the facts and a pressing of the facts to make them fit the theory...
The temptation to misinterpret results that contradict the desired hypothesis is probably irresistible. 
Despite the admonitions of Platt, reviewers of grant-applications often require "A Hypothesis" as part of the proposal (note the singular). Peer-review of research can help avoid the mistakes of single-hypotheses, but only so long as the reviewers are not in the thrall of the same hypothesis. If there is a shared enthrallment among the reviewers in a commonly believed hypothesis, then innovation becomes difficult because alternative hypotheses are not seriously considered, and sometimes not even permitted.
The method, very similar to the scientific method, is described as:
- Devising alternative hypotheses;
- Devising a crucial experiment (or several of them), with alternative possible outcomes, each of which will, as nearly as possible, exclude one or more of the hypotheses;
- Carrying out the experiment(s) so as to get a clean result;
- Recycling the procedure, making subhypotheses or sequential hypotheses to refine the possibilities that remain, and so on.
Strong inference plus
The limitations of Strong-Inference can be corrected by having two preceding phases:
- An exploratory phase: at this point information is inadequate so observations are chosen randomly or intuitively or based on scientific creativity.
- A pilot phase: in this phase statistical power is determined by replicating experiments under identical experimental conditions.
These phases create the critical seed observation(s) upon which one can base alternative hypotheses.
- John R. Platt (1964). "Strong inference". Science. 146 (3642): 347–53. Bibcode:1964Sci...146..347P. doi:10.1126/science.146.3642.347. PMID 17739513.
- Don L. Jewett (1 January 2005). "What's wrong with single hypotheses? Why it is time for Strong-Inference-PLUS". Scientist (Philadelphia, Pa.). 19 (21): 10. PMC . PMID 17975652.
- O'Donohue, William; Buchanan, Jeffrey A. (2001). "The weaknesses of strong inference". Behavior and Philosophy. Cambridge Center for Behavioral Studies. 29: 1–20.
- Rowland H. Davis (2006). "Strong Inference: rationale or inspiration?". Perspectives in Biology and Medicine. 49 (2): 238–250. doi:10.1353/pbm.2006.0022. PMID 16702707.
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