|Micrograph showing strongyloidiasis; a fragment of a worm is seen in the lower right hand corner. H&E stain.|
Strongyloidiasis is a human parasitic disease caused by the nematode called Strongyloides stercoralis, or sometimes S. fülleborni which is a type of helminth. It belongs to a group of nematodes called roundworms. This intestinal worm can cause a number of symptoms in people, principally skin symptoms, abdominal pain, diarrhea and weight loss, among many other specific and vague symptoms in disseminated disease, and severe life threatening conditions through hyperinfection. In some people, particularly those who require corticosteroids or other immunosuppressive medication, Strongyloides can cause a hyperinfection syndrome that can lead to death if untreated. The diagnosis is made by blood and stool tests. The medication ivermectin is widely used to treat strongyloidiasis.
Strongyloidiasis is a type of soil-transmitted helminthiasis. Low estimates postulate it to affect 30–100 million people worldwide, mainly in tropical and subtropical countries, while higher estimates conservatively extrapolate that infection is upwards to or above 370 million people. It belongs to the group of neglected tropical diseases, and worldwide efforts are aimed at eradicating the infection.
Signs and symptoms
Strongyloides infection occurs in five forms. As the infection continues and the larvae matures, there may be respiratory symptoms (Löffler's syndrome). The infection may then become chronic with mainly digestive symptoms. On reinfection (when larvae migrate through the body) from the skin to the lungs and finally to the small intestine, there may be respiratory, skin and digestive symptoms. Finally, the hyperinfection syndrome causes symptoms in many organ systems, including the central nervous system.
Frequently asymptomatic. Gastrointestinal system symptoms include abdominal pain and diarrhea and/or conversely constipation. Pulmonary symptoms (including Löffler's syndrome) can occur during pulmonary migration of the filariform larvae. Pulmonary infiltrate may be present through radiological investigation. Dermatologic manifestations include urticarial rashes in the buttocks and waist areas as well as larva currens. Eosinophilia is generally present.
Strongyloidiasis can become chronic and then become completely asymptomatic.
Disseminated strongyloidiasis occurs when patients with chronic strongyloidiasis become immunosuppressed. There is a distinction to be made between dissemination and hyperinfection. It is mainly a semantic distinction. There can be mild dissemination where the worm burden is relatively lower yet causes insidious symptoms, or extreme dissemination that the term hyperinfection is used to describe. Thus hyperinfection of varying levels of severe dissemination may present with abdominal pain, distension, shock, pulmonary and neurologic complications, sepsis, haemorrhage, malabsorption, and depending on the combination, degree, number, and severity of symptoms, is potentially fatal. The worms enter the bloodstream from the bowel wall, simultaneously allowing entry of bowel bacteria such as Escherichia coli. This may cause symptoms such as sepsis (bloodstream infection), and the bacteria may spread to other organs where they may cause localized infection such as meningitis. Dissemination without hyperinfection may present to a lesser degree the above and many other symptoms.
Dissemination can occur many decades after the initial infection and has been associated with high dose corticosteroids, organ transplant, any other instances and causes of immunosuppression, HIV, lepromatous leprosy, tertiary syphilis, aplastic anemia, malnutrition, advanced tuberculosis and radiation poisoning. It is often recommended that patients being started on immunosuppression be screened for chronic strongyloidiasis; however, this is often impractical (screen tests are often unavailable) and in developed countries, the prevalence of chronic strongyloidiasis is very small, so screening is usually not cost-effective, except in endemic areas. The reality of global travel and need for modern advanced healthcare, even in the so-called "developed world", necessitates that in non-endemic areas there is easily accessible testing and screening for neglected tropical diseases such as strongyloidiasis.
It is important to note that there is not necessarily any eosinophilia in the disseminated disease. Absence of eosinophilia in an infection limited to the gastrointenstinal tract may indicate poor prognosis. Eosinophilia is often absent in disseminated infection. Steroids will also suppress eosinophilia, while leading to dissemination and potential hyperinfection.
Escalated disseminated infections caused by immunosuppression can result in a wide variety and variable degree of disparate symptoms depending on the condition and other biological aspects of the individual, that may emulate other diseases or diagnoses. In addition to the many palpable gastrointestinal and varied other symptoms drastic cachexia amidst lassitude is often present, although severe disseminated infections can occur in individuals without weight loss regardless of body mass index.
Diagnosis rests on the microscopic identification of larvae (rhabditiform and occasionally filariform) in the stool or duodenal fluid. Examination of many samples may be necessary, and not always sufficient, because direct stool examination is relatively insensitive, with a single sample only able to detect larvae in about 25% of cases. It can take 4 weeks from initial infection to the passage of larvae in the stool.
The stool can be examined in wet mounts:
- after concentration (formalin-ethyl acetate)
- after recovery of the larvae by the Baermann funnel technique
- after culture by the Harada-Mori filter paper technique
- after culture in agar plates
Culture techniques are the most sensitive, but are not routinely available in the West. In the UK, culture is available at either of the Schools of Tropical Medicine in Liverpool or London. Direct examination must be done on stool that is freshly collected and not allowed to cool down, because hookworm eggs hatch on cooling and the larvae are very difficult to distinguish from Strongyloides.
Finding Strongyloides in the stool is negative in up to 70% of tests. It is important to undergo frequent stool sampling as well as duodenal biopsy if a bad infection is suspected. The duodenal fluid can be examined using techniques such as the Enterotest string or duodenal aspiration. Larvae may be detected in sputum from patients with disseminated strongyloidiasis.
Given the poor ability of stool examination to diagnose strongyloides, detecting antibodies by ELISA can be useful. Serology can cross-react with other parasites, remain positive for years after successful treatment or be falsely negative in immunocompromised patients. Infected patients will also often have an elevated eosinophil count, with an average of absolute eosinophil count of 1000 in one series. Eosinophilia of a gastrointestinal infection may fluctuate in response to larval output, or may be permanently lacking in some disseminated infections. Hence lack of eosinophilia is not evidence of absence of infection. The combination of clinical suspicion, a positive antibody and a peripheral eosinophilia can be strongly suggestive of infection.
It would be greatly useful to have significant advances in the sensitivity of the means of diagnosis, as it would also solve the challenging problem of proof of cure. If definitive diagnosis is solved then it stands to reason that proof of cure becomes easily realizable.
The consensus drug of choice for the treatment of uncomplicated strongyloidiasis is ivermectin. However, even if it is considered the main drug of choice, recent studies have illustrated the challenges in ivermectin curing strongyloidiasis. Ivermectin does not kill the Strongyloides larvae, only the adult worms, therefore repeat dosing may be necessary to properly eradicate the infection. There is an auto-infective cycle of roughly two weeks in which ivermectin should be re-administered however additional dosing may still be necessary as it will not kill Strongyloides in the blood or larvae deep within the bowels or diverticula. Other drugs that can be effective are albendazole and thiabendazole (25 mg/kg twice daily for 5 days—400 mg maximum (generally)). All patients who are at risk of disseminated strongyloidiasis should be treated. The optimal duration of treatment for patients with disseminated infections is not clear.
Treatment of strongyloidiasis can be difficult and if ceasing treatment before being entirely cleared Strongyloides via the autoinfective cycle has been known to live in individuals for decades; even after initial or inadequate sustained treatment. Continued treatment, blood and stool monitoring thus may be necessary even if symptoms temporarily resolve. As cited earlier, due to the fact that some infections are insidiously asymptomatic, and relatively expensive bloodwork is often inconclusive via false-positives or false-negatives, just as stool samples can be unreliable in diagnoses, there is yet unfortunately no real gold standard for proof of cure, mirroring the lack of an efficient and reliable methodology of diagnosis. An objective eradication standard for strongyloidiasis is elusive given the high degree of suspicion needed to even begin treatment, the sometimes difficulty of the only definitive diagnostic criteria of detecting and isolating larvae or adult strongyloides, the importance of early diagnosis, particularly before steroid treatments, and the very wide variability and exclusion/inclusion of differing collections of diffuse symptoms. Disregarding mis-ascribing bonafide delusional parasitosis disorders, strongyloidiasis should be more well known among medical professionals and have serious consideration for broad educational campaigns in effected geographic locales both within the semi-tropical developed world and otherwise, as well as in the tropical developing world where, among many other neglected tropical diseases, it is endemic.
Government programs are needed to help decontaminate endemic areas and to help effected populations from infection. Furthermore progress is required in establishing financial support to facilitate and cover affordable medications for individuals in effected at-risk regions and communities to help continuing treatments.
There are conflicting reports on effective drug treatments. Ivermectin ineffectiveness and rising drug resistance has been documented. Albendazole is noted by the WHO as being the least effective. Thiabendazole can have severe side effects and is unavailable in many countries. Major inroads are required to advance the development of successful medications and drug protocols for strongyloidiasis and other neglected tropical diseases.
Contagiousness via textiles, unlike enterobius vermicularis, is unfounded. As is, generally speaking, person to person contagiousness of asymptomatic and disseminated infection. It has rarely been transmitted through organ transplantation. Married Vietnam War veterans who were infected, yet never developed significant hyperinfection, lived for multiple decades with non-debilitating disseminated infection, without treatment, with wives who failed to ever contract infection. Contraction occurs overwhelmingly from skin exposure to any contaminated soil, contaminated potting soil, contaminated waters, lack of sanitation, or environmental factors as potential vectors. Nearly never to extraordinarily very rarely documented is transmission from person to person (besides from infected male homosexual sex), other than closeness of contact to the productive coughing of a very ill hyperinfected individual. It has been shown possible to occur in that situation, or potentially other similar scenarios, it is speculated via pulmonary secretions of a direly hyperinfected individual. In which case treatment for others may be indicated, if deemed necessary by proximity, symptoms, precautions, probable exposures to the same vectors, or through screening of serology and stool samples, until infection is eradicated.
Before administering steroids at least somewhat screening for infection in even remotely potentially susceptible individuals in order to prevent escalating the infection is advised. As not doing so in certain cohorts can have extremely high mortality rates from inadvertently caused hyperinfection via immunosuppression of application of certain steroids. Thus extreme caution with respect to iatrogenic risks is crucial to avoiding deaths or other adverse consequences in treatment, that of course prefigures a correct diagnosis.
The disease was first recognized in 1876 by the French physician Louis Alexis Normand, working in the naval hospital in Toulon; he identified the adult worms, and sent them to Arthur Réné Jean Baptiste Bavay, chief inspector for health, who observed that these were the adult forms of the larvae found in the stool. In 1883 the German parasitologist Rudolf Leuckart made initial observations on the life cycle of the parasite, and Belgian physician Paul Van Durme (building on observations by the German parasitologist Arthur Looss) described the mode of infection through the skin. The German parasitologist Friedrich Fülleborn described autoinfection and the way by which strongyloidiasis involves the intestine. Interest in the condition increased in the 1940s when it was discovered that those who had acquired the infection abroad and then received immunosuppression developed hyperinfestation syndrome.
- Buonfrate D, Formenti F, Perandin F, Bisoffi Z (June 2015). "Novel approaches to the diagnosis of Strongyloides stercoralis infection". Clinical Microbiology and Infection. 21 (6): 543–52. doi:10.1016/j.cmi.2015.04.001. PMID 25887711.
- Varatharajalu R, Kakuturu R (2016). "Strongyloides stercoralis: Current perspectives". Reports in Parasitology: 23. doi:10.2147/RIP.S75839.
- "Neglected Tropical Diseases". cdc.gov. June 6, 2011. Retrieved 28 November 2014.
- Montes M, Sawhney C, Barros N (October 2010). "Strongyloides stercoralis: there but not seen". Current Opinion in Infectious Diseases. 23 (5): 500–4. doi:10.1097/QCO.0b013e32833df718. PMC 2948977. PMID 20733481.
- Marcos LA, Terashima A, Dupont HL, Gotuzzo E (April 2008). "Strongyloides hyperinfection syndrome: an emerging global infectious disease". Transactions of the Royal Society of Tropical Medicine and Hygiene. 102 (4): 314–8. doi:10.1016/j.trstmh.2008.01.020. PMID 18321548.
- Arthur RP, Shelley WB (August 1958). "Larva currens; a distinctive variant of cutaneous larva migrans due to Strongyloides stercoralis". AMA Archives of Dermatology. 78 (2): 186–90. doi:10.1001/archderm.1958.01560080044007. PMID 13558704.
- Ghoshal UC, Ghoshal U, Jain M, Kumar A, Aggarwal R, Misra A, Ayyagari A, Naik SR (December 2002). "Strongyloides stercoralis infestation associated with septicemia due to intestinal transmural migration of bacteria". Journal of Gastroenterology and Hepatology. 17 (12): 1331–3. doi:10.1046/j.1440-1746.2002.02750.x. PMID 12423282.
- Graeff-Teixeira C, da Silva AC, Yoshimura K (April 2009). "Update on eosinophilic meningoencephalitis and its clinical relevance". Clinical Microbiology Reviews. 22 (2): 322–48, Table of Contents. doi:10.1128/CMR.00044-08. PMC 2668237. PMID 19366917.
- Gill GV, Beeching NJ, Khoo S, Bailey JW, Partridge S, Blundell JW, Luksza AR (June 2004). "A British Second World War veteran with disseminated strongyloidiasis". Transactions of the Royal Society of Tropical Medicine and Hygiene. 98 (6): 382–6. doi:10.1016/j.trstmh.2003.11.002. PMID 15099996.
- Kramer MR, Gregg PA, Goldstein M, Llamas R, Krieger BP (October 1990). "Disseminated strongyloidiasis in AIDS and non-AIDS immunocompromised hosts: diagnosis by sputum and bronchoalveolar lavage". Southern Medical Journal. 83 (10): 1226–9. doi:10.1097/00007611-199010000-00024. PMID 2218668.
- Gompels MM, Todd J, Peters BS, Main J, Pinching AJ (March 1991). "Disseminated strongyloidiasis in AIDS: uncommon but important". AIDS. 5 (3): 329–32. doi:10.1097/00002030-199103000-00015. PMID 2059374.
- Purtilo DT, Meyers WM, Connor DH (April 1974). "Fatal strongyloidiasis in immunosuppressed patients". The American Journal of Medicine. 56 (4): 488–93. doi:10.1016/0002-9343(74)90481-1. PMID 4818417.
- Gokhale UA, Pillai GR, Al-Mammari S, Al-Layla D (2010). "Hyperinfection by Strongyloides Stercoralis". Oman Medical Journal. 25 (2): 163–6. doi:10.5001/omj.2010.47 (inactive 2019-08-20).
- Segarra-Newnham M (December 2007). "Manifestations, diagnosis, and treatment of Strongyloides stercoralis infection". The Annals of Pharmacotherapy. 41 (12): 1992–2001. doi:10.1345/aph.1K302. PMID 17940124.
- Beal CB, Viens P, Grant RG, Hughes JM (March 1970). "A new technique for sampling duodenal contents: demonstration of upper small-bowel pathogens". The American Journal of Tropical Medicine and Hygiene. 19 (2): 349–52. doi:10.4269/ajtmh.1970.19.349. PMID 5443084.
- Carroll SM, Karthigasu KT, Grove DI (1981). "Serodiagnosis of human strongyloidiasis by an enzyme-linked immunosorbent assay". Transactions of the Royal Society of Tropical Medicine and Hygiene. 75 (5): 706–9. doi:10.1016/0035-9203(81)90156-5. PMID 7036430.
- Greiner K, Bettencourt J, Semolic C (2008). "Strongyloidiasis: a review and update by case example". Clinical Laboratory Science. 21 (2): 82–8. PMID 18507302.
- Nuesch R, Zimmerli L, Stockli R, Gyr N, Christoph Hatz FR (2006). "Imported strongyloidosis: a longitudinal analysis of 31 cases". Journal of Travel Medicine. 12 (2): 80–4. doi:10.2310/7060.2005.12204. PMID 15996452.
- Mendes T, Minori K, Ueta M, Miguel DC, Allegretti SM (2017). "Strongyloidiasis Current Status with Emphasis in Diagnosis and Drug Research". Journal of Parasitology Research. 2017: 5056314. doi:10.1155/2017/5056314. PMC 5292188. PMID 28210503.
- Repetto SA, Ruybal P, Batalla E, López C, Fridman V, Sierra M, Radisic M, Bravo PM, Risso MG, González Cappa SM, Alba Soto CD (May 2018). "Strongyloidiasis Outside Endemic Areas: Long-term Parasitological and Clinical Follow-up After Ivermectin Treatment". Clinical Infectious Diseases. 66 (10): 1558–1565. doi:10.1093/cid/cix1069. PMID 29360939.
- Strongyloidiasis~treatment at eMedicine
- "Strongyloidiasis" (PDF). Australian Government.
- "Strongyloides Antibody, IgG, Serum". Mayo Clinic.
- Siddiqui AA, Berk SL (October 2001). "Diagnosis of Strongyloides stercoralis infection". Clinical Infectious Diseases. 33 (7): 1040–7. doi:10.1086/322707. PMID 11528578.
- Lodh N, Caro R, Sofer S, Scott A, Krolewiecki A, Shiff C (November 2016). "Diagnosis of Strongyloides stercoralis: Detection of parasite-derived DNA in urine". Acta Tropica. 163: 9–13. doi:10.1016/j.actatropica.2016.07.014. PMC 5117362. PMID 27456935.
- Kassalik M, Mönkemüller K (November 2011). "Strongyloides stercoralis hyperinfection syndrome and disseminated disease". Gastroenterology & Hepatology. 7 (11): 766–8. PMC 3264932. PMID 22298975.
- "Delusional Parasitosis". Merck Manual.
- Prakash J, Shashikumar R, Bhat PS, Srivastava K, Nath S, Rajendran A (January 2012). "Delusional parasitosis: Worms of the mind". Industrial Psychiatry Journal. 21 (1): 72–4. doi:10.4103/0972-6748.110958. PMC 3678185. PMID 23766584.
- Bak R, Tumu P, Hui C, Kay D, Peng D (October 2008). "A review of delusions of parasitosis, part 2: treatment options". Cutis. 82 (4): 257–64. PMID 19055169.
- Buonfrate D, Requena-Mendez A, Angheben A, Muñoz J, Gobbi F, Van Den Ende J, Bisoffi Z (February 2013). "Severe strongyloidiasis: a systematic review of case reports". BMC Infectious Diseases. 13: 78. doi:10.1186/1471-2334-13-78. PMC 3598958. PMID 23394259.
- Boulware DR, Stauffer WM, Hendel-Paterson BR, Rocha JL, Seet RC, Summer AP, Nield LS, Supparatpinyo K, Chaiwarith R, Walker PF (June 2007). "Maltreatment of Strongyloides infection: case series and worldwide physicians-in-training survey". The American Journal of Medicine. 120 (6): 545.e1–8. doi:10.1016/j.amjmed.2006.05.072. PMC 1950578. PMID 17524758.
- Kearns TM, Currie BJ, Cheng AC, McCarthy J, Carapetis JR, Holt DC, Page W, Shield J, Gundjirryirr R, Mulholland E, Ward L, Andrews RM (May 2017). "Strongyloides seroprevalence before and after an ivermectin mass drug administration in a remote Australian Aboriginal community". PLoS Neglected Tropical Diseases. 11 (5): e0005607. doi:10.1371/journal.pntd.0005607. PMC 5444847. PMID 28505198.
- Whiley H, Ross K, Beknazarova M (5 September 2017). "Strongyloidiasis is a deadly worm infecting many Australians, yet hardly anybody has heard of it". The Conversation.
- Repetto SA, Ruybal P, Batalla E, López C, Fridman V, Sierra M, Radisic M, Bravo PM, Risso MG, González Cappa SM, Alba Soto CD (May 2018). "Strongyloidiasis Outside Endemic Areas: Long-term Parasitological and Clinical Follow-up After Ivermectin Treatment". Clinical Infectious Diseases. 66 (10): 1558–1565. doi:10.1093/cid/cix1069. PMID 29360939. Lay summary – Infectious Disease Advisor (February 23, 2018).
- "Strongyloidiasis". World Health Organization.
- "Thiabendazole". United States National Institutes of Health.
- "Strongyloides stercoralis (Strongyloidiasis)". AntiMicrobe.
- "Strongyloidiasis Infection FAQs". United States Centers for Disease Control and Prevention (CDC). 2019-04-23.
- Grove DI (August 1982). "Strongyloidiasis: is it transmitted from husband to wife?". The British Journal of Venereal Diseases. 58 (4): 271–2. doi:10.1136/sti.58.4.271. PMC 1046065. PMID 6896668.
- Czachor JS, Jonas AP (2006). "Transmission of Strongyloides steracolis person to person". Journal of Travel Medicine. 7 (4): 211–2. doi:10.2310/7060.2000.00063. PMID 11003736.
- Kim YK, Kim H, Park YC, Lee MH, Chung ES, Lee SJ, Kim MS (July 1989). "A case of hyperinfection with strongyloides stercoralis in an immunosuppressed patient". The Korean Journal of Internal Medicine. 4 (2): 165–70. doi:10.3904/kjim.1918.104.22.168. PMC 4534981. PMID 2486847.
- Page W, Speare R (2016). "Chronic strongyloidiasis - Don't look and you won't find". Australian Family Physician. 45 (1): 40–4. PMID 27051986.
- Cox FE (October 2002). "History of human parasitology". Clinical Microbiology Reviews. 15 (4): 595–612. doi:10.1128/CMR.15.4.595-612.2002. PMC 126866. PMID 12364371.