Structure specific recognition protein 1

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SSRP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSSRP1, FACT, FACT80, T160, Structure specific recognition protein 1
External IDsMGI: 107912 HomoloGene: 110735 GeneCards: SSRP1
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for SSRP1
Genomic location for SSRP1
Band11q12.1Start57,325,985 bp[1]
End57,335,877 bp[1]
RNA expression pattern
PBB GE SSRP1 200957 s at fs.png

PBB GE SSRP1 200956 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003146

NM_001136081
NM_182990

RefSeq (protein)

NP_003137

NP_001129553
NP_892035

Location (UCSC)Chr 11: 57.33 – 57.34 MbChr 2: 85.04 – 85.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FACT complex subunit SSRP1 also known as structure specific recognition protein 1 is a protein that in humans is encoded by the SSRP1 gene.[5]

Function[edit]

The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63.[5]

Interactions[edit]

Structure specific recognition protein 1 has been shown to interact with NEK9.[6] SSRP1 further interacts with transcriptional activator p63.[7] SSRP1 enhances the activity of full-length p63, but it has no effect on the N-terminus-deleted p63 (DeltaN-p63) variant.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149136 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027067 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: SSRP1 structure specific recognition protein 1".
  6. ^ Tan BC, Lee SC (Mar 2004). "Nek9, a novel FACT-associated protein, modulates interphase progression". J. Biol. Chem. 279 (10): 9321–30. doi:10.1074/jbc.M311477200. PMID 14660563.
  7. ^ Zeng SX, Dai MS, Keller DM, Lu H (15 Oct 2002). "SSRP1 functions as a co-activator of the transcriptional activator p63". EMBO J. 21 (20): 5487–97. doi:10.1093/emboj/cdf540. PMC 129072. PMID 12374749.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.