Structure specific recognition protein 1

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Structure specific recognition protein 1
Identifiers
Symbols SSRP1 ; FACT; FACT80; T160
External IDs OMIM604328 MGI107912 HomoloGene110735 GeneCards: SSRP1 Gene
RNA expression pattern
PBB GE SSRP1 200957 s at tn.png
PBB GE SSRP1 200956 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6749 20833
Ensembl ENSG00000149136 ENSMUSG00000027067
UniProt Q08945 Q08943
RefSeq (mRNA) NM_003146 NM_001136081
RefSeq (protein) NP_003137 NP_001129553
Location (UCSC) Chr 11:
57.09 – 57.1 Mb
Chr 2:
85.04 – 85.05 Mb
PubMed search [1] [2]

Structure specific recognition protein 1, also known as SSRP1, is a human protein.[1]

The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63.[1]

Interactions[edit]

Structure specific recognition protein 1 has been shown to interact with NEK9.[2] SSRP1 further interacts with transcriptional activator p63.[3] SSRP1 enhances the activity of full-length p63, but it has no effect on the N-terminus-deleted p63 (DeltaN-p63) variant.

References[edit]

  1. ^ a b "Entrez Gene: SSRP1 structure specific recognition protein 1". 
  2. ^ Tan, Bertrand Chin-Ming; Lee Sheng-Chung (Mar 2004). "Nek9, a novel FACT-associated protein, modulates interphase progression". J. Biol. Chem. (United States) 279 (10): 9321–30. doi:10.1074/jbc.M311477200. ISSN 0021-9258. PMID 14660563. 
  3. ^ Zeng, SX; Dai MS, Keller DM, Lu H (15 Oct 2002). "SSRP1 functions as a co-activator of the transcriptional activator p63". EMBO J. 21 (20): 5487–97. doi:10.1093/emboj/cdf540. PMC 129072. PMID 12374749. Retrieved 23 February 2012. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.