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Subependymoma - high mag.jpg
Micrograph of a subependymoma showing the characteristic clustering of nuclei. H&E stain.
Classification and external resources
ICD-O 9383/1
DiseasesDB 34807
Subependymomas of the fourth ventricle, extending into the cerebellopontine angle via the foramen of Luschka, right side of illustration.

A subependymoma is a type of brain tumor; specifically, it is a rare form of ependymal tumor.[1]

The prognosis for a subependymoma is better than for most ependymal tumors,[2] and is considered a grade I/IV tumor in the World Health Organization (WHO) classification.

They are classically found within the fourth ventricle, typically have a well demarcated interface to normal tissue and do not usually extend into the brain parenchyma, like ependymomas often do.[3]


The diagnosis is based on tissue, e.g. a biopsy. Histologically subependymomas consistent of microcystic spaces and bland appearing cells without appreciable nuclear atypia or mitoses. The nuclei tend to form clusters.


  1. ^ Orakcioglu B, Schramm P, Kohlhof P, Aschoff A, Unterberg A, Halatsch ME (January 2009). "Characteristics of thoracolumbar intramedullary subependymomas". J Neurosurg Spine. 10 (1): 54–9. doi:10.3171/2008.10.SPI08311. PMID 19119934. 
  2. ^ Prayson RA, Suh JH (April 1999). "Subependymomas: clinicopathologic study of 14 tumors, including comparative MIB-1 immunohistochemical analysis with other ependymal neoplasms". Arch. Pathol. Lab. Med. 123 (4): 306–9. doi:10.1043/0003-9985(1999)123<0306:S>2.0.CO;2. PMID 10320142. 
  3. ^ Hoeffel, C.; Boukobza, M.; Polivka, M.; Lot, G.; Guichard, JP.; Lafitte, F.; Reizine, D.; Merland, JJ. (1995). "MR manifestations of subependymomas.". AJNR Am J Neuroradiol. 16 (10): 2121–9. PMID 8585504.