Subhash Chandra Lakhotia
Subhash Chandra Lakhotia
|Residence||Varanasi, Uttar Pradesh, India|
|Known for||Cellular autonomy of the hyperactive male-X for dosage compensation in Drosophila, contributions to understanding of the long-non-coding RNA 93D or the hsromega gene locus of Drosophila melanogaster, contributions to Ayurvedic Biology and for discussions/writings on higher education and research assessment policies|
|Awards||1975 INSA Young Scientists Medal|
1979 UGC Career Award in Sciences
1989 Shanti Swarup Bhatnagar Prize
1998 UGC J. C. Bose Award
2002 INSA Sunder Lal Hora Medal
2007 BHU Professor CNR Rao Education Foundation Award
|Doctoral advisor||Prof. Ardhendu Shekhar Mukherjee|
Subhash Chandra Lakhotia (born 1945) is an Indian cytogeneticist, academic and a Distinguished Professor of zoology and an INSA senior scientist at Banaras Hindu University. He is known for his pioneering researches on Drosophila with regard to its chromosome organization and replication. A Raja Ramanna fellow of the Department of Science and Technology and the Department of Atomic Energy, he is an elected fellow of all the three major Indian science academies viz. Indian National Science Academy, Indian Academy of Sciences and National Academy of Sciences, India. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 1989, for his contributions to biological sciences.
Subhash Chandra Lakhotia, born on 4 October 1945 in Churu, a city near Thar desert in the Indian state of Rajasthan, to Dwarka Prasad-Suryakala couple, did his early schooling in Churu and then in Kolkata and graduated from Vidyasagar College, Calcutta University in Zoology Honours in 1964 before obtaining his master's degree in Zoology and Comparative Anatomy in 1966, both from Calcutta University. Continuing his doctoral studies at the same university at the Zoology Department, he secured his PhD in 1970, did his post-doctoral studies at Delhi University during 1970–71 and started his career as a Lecturer at Burdwan University in 1971. Moving to Gujarat University in June 1972, he stayed there till September 1976 before joining the Banaras Hindu University as a Reader. He became full Professor in 1984 and continued there till superannuation in 2010. In between, he carried out some advanced studies at the Institute of Animal Genetics of the University of Edinburgh during 1972-73, at the University of California, Irvine during 1984-85 and at Massachusetts Institute of Technology, Cambridge in 1985. Post his formal superannuation, he continues his academic activities at the Banaras Hindu University as INSA senior scientist  and as life-long Distinguished Professor.
Lakhotia's researches are focused on cytogenetics and cell biology. He carried out pioneering research on Drosophila (fruit flies) with regard to its chromosome organization and replication, and on organization and functions of the long-non-coding RNA 93D or the hsromega gene locus of Drosophila melanogaster. During his doctoral studies on dosage compensation in Drosophila he further confirmed the hyperactive male-X model and elucidated its cellular autonomy. His discovery of active transcription in heterochromatin in Drosophila in early 1970s was one of the first documentation of transcriptional activity of heterochromatin. His later studies revealed the existence of two distinct replicon types in different cell types of Drosophila. He has been a pioneer researcher studying the long non-coding RNAs since 1980s and has contributed significantly to a wider appreciation of their function through sustained studies on the hsromega gene. https://www.ias.ac.in/article/fulltext/jbsc/036/03/0399-0423 His laboratory discovered the omega speckles http://jcs.biologists.org/content/113/19/3485 in Drosophila nuclei and established essential functions of the lncRNAs produced by the hsromega gene in organization of the intra-nuclear omega speckles. His studies also helped identify how this lncRNA gene modulates apoptosis and neurodegeneration in Drosophila models of human diseases. More recently, he established Drosophila as a good model to understand the mechanisms of actions of some of the ayurvedic formulations. His studies indicate that the Ayurvedic Amalaki Rasayana and Rasa-Sindoor can substantially suppress neurodegeneration associated with polyQ and Alzheimer's disorders. He has published more than 130 original research papers, available at PubMed, an online repository of medical articles, and at ResearchGate . He has also published many reviews, has contributed chapters to books published by others and has mentored more than 30 scholars in their doctoral studies.
Lakhotia contributed to the establishment of the Department of Molecular and Human Genetics at Banaras Hindu University and to the installation of Confocal microscope facility at his department. Besides his research contributions, Lakhotia is also well known for his many writings on education,"Subhash Chandra Lakhotia on ResearchGate". ResearchGate. 2016. Retrieved 4 October 2016. he served as a member of one of the sub-committees of the National Knowledge Commission, sat in the Committee on Science Education of the International Council for Science (ICSU) in 2010 and was a member of its review panel. He was associated with the International Union of Biological Sciences, was a member of its executive committee during 2000–03 and served as its vice president from 2003 to 2006. He is a former member of INSA council, a former vice president, and the vice president of its Inter-Academy Exchange Committee. He is the editor-in-chief of its journal (Proceedings of the Indian National Science Academy). He has been associated with the Council of Scientific and Industrial Research, University Grants Commission of India, Department of Atomic Energy, Department of Science and Technology and Department of Biotechnology as a member of their various committees and has served or is continuing as a member of the editorial boards of journals such as Current Science, Journal of Biosciences, RNA Biology, Cell Stress and Chaperones and Annals of Neurosciences. He is a life member of Indian Society of Cell Biology, Indian Society of Developmental Biology, Cell Stress Society International, Genetics Society of America and RNA Society. Recently, he was elected a Senior Fellow of the Cell Stress Society International.
Awards and honors
Lakhotia received the Young Scientists Medal of the Indian National Science Academy in 1975 and the Career Award in Sciences of the University Grants Commission of India (UGC) in 1979. The Council of Scientific and Industrial Research awarded him the Shanti Swarup Bhatnagar Prize, one of the highest Indian science awards in 1989, the same year as he was selected as the National Lecturer by the UGC. The Commission honored him again in 1998 with the J. C. Bose Award and he received INSA Sunder Lal Hora Medal in 2002. Five years later, Banaras Hindu University awarded him the 2007 Professor CNR Rao Education Foundation Award.
Lakhotia has held the Ramanna fellowship of the Department of Science and Technology from 2009 and the Raja Ramanna Fellowship of the Department of Atomic Energy from 2011. Besides, he held the Jawaharlal Nehru Birth Centenary Fellowship of the Indian National Science Academy in 2009. He was elected as a fellow by the Indian National Science Academy in 1993, by the Indian Academy of Sciences in 1994 and by the National Academy of Sciences, India in 2002. He was elected the Senior Fellow of the Cell Stress Society International in 2017. He has also delivered several award lectures including the 18th G. J. S. Rao Memorial Award Lecture of the Indian Institute of Science in 2011.
- "Distinguished Professor".
- "Faculty of Science". Banaras Hindu University. 2016. Retrieved 4 October 2016.
- "Brief Profile of the Awardee". Shanti Swarup Bhatnagar Prize. 2016. Retrieved 28 September 2016.
- "Indian Fellow - Lakhotia". Indian National Science Academy. 2016. Retrieved 30 September 2016.
- "View Bhatnagar Awardees". Shanti Swarup Bhatnagar Prize. 2016. Retrieved 19 September 2016.
- "Chandra Lakhotia". My Heritage. 2016. Retrieved 4 October 2016.
- "Handbook of Shanti Swarup Bhatnagar Prize Winners" (PDF). Council of Scientific and Industrial Research. 1999. p. 29. Retrieved 28 September 2016.
- Lakhotia SC (1989). "The 93D heat shock locus of Drosophila melanogaster: modulation by genetic and developmental factors". Genome. 31 (2): 677–83. doi:10.1139/g89-124. PMID 2517262.
- Advances in Genetics. Academic Press. 4 May 1999. pp. 81–. ISBN 978-0-08-056826-3.
- "Subhash C. Lakhotia Retired Professor". Banaras Hindu University. 2016. Retrieved 4 October 2016.
- "Lakhotia on PubMed". Author profile. PubMed. 2016. Retrieved 4 October 2016.
- "Subhash Chandra Lakhotia on ResearchGate". ResearchGate. 2016. Retrieved 4 October 2016.
- "Review Panel members". International Council for Science. 2016. Retrieved 4 October 2016.
- "IUBS boards". International Union of Biological Sciences. 2016. Retrieved 4 October 2016.
- "Recent Past Vice-presidents". INSA. 2016. Retrieved 4 October 2016.
- "Inter-Academy Exchange Committee". INSA. 2016. Retrieved 4 October 2016.
- "Subhash Chandra Lakhotia - Research experience". ResearchGate. 2016. Retrieved 4 October 2016.
- "Young Scientists Medal". Indian National Science Academy. 2016. Retrieved 4 October 2016.
- "The Sunder Lal Hora Medal". INSA. 2016. Retrieved 4 October 2016.
- "Fellow profile - Indian Academy of Sciences". Indian Academy of Sciences. 2016. Retrieved 30 September 2016.
- "NASI fellows". National Academy of Sciences, India. 2016. Retrieved 3 October 2016.