Sucrose synthase

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 Ribbon Diagram of Sucrose Synthase-1 3S27.
Ribbon diagram of Sucrose Synthase-1 3S27 Structure, isolated from Arabidopsis thaliana.[1]
sucrose synthase
Identifiers
EC number 2.4.1.13
CAS number 9030-05-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Sucrose synthase
Identifiers
Symbol Sucrose_synth
Pfam PF00862
InterPro IPR000368

In enzymology, a sucrose synthase (EC 2.4.1.13) is an enzyme that catalyzes the chemical reaction

NDP-glucose + D-fructose NDP + sucrose

Thus, the two substrates of this enzyme are NDP-glucose and D-fructose, whereas its two products are NDP and sucrose.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is NDP-glucose:D-fructose 2-alpha-D-glucosyltransferase. Other names in common use include UDPglucose-fructose glucosyltransferase, sucrose synthetase, sucrose-UDP glucosyltransferase, sucrose-uridine diphosphate glucosyltransferase, and uridine diphosphoglucose-fructose glucosyltransferase. This enzyme participates in starch and sucrose metabolism.

References[edit]

  1. ^ Zheng, Yi; Spencer, A.; Zhang, Y.; Garavito, R.M. (24 August 2011). "The Structure of Sucrose Synthase-1 from Arabidopsis thaliana and its Functional Implications". Journal of Biological Chemistry. 286: 36108–36118. doi:10.1074/jbc.M111.275974. PMC 3195635Freely accessible. PMID 21865170. ; rendered with PyMOL

Literature[edit]

  • Avigad G; Milner Y (1966). "UDP-glucose:fructose transglucosylase from sugar beet roots". Methods Enzymol. 8: 341–345. doi:10.1016/0076-6879(66)08063-7. 
  • CARDINI CE, LELOIR LF, CHIRIBOGA J (1955). "The biosynthesis of sucrose". J. Biol. Chem. 214 (1): 149–55. PMID 14367373. 
  • Delmer DP (1972). "The purification and properties of sucrose synthetase from etiolated Phaseolus aureus seedlings". J. Biol. Chem. 247 (12): 3822–8. PMID 4624446. 
  • Murata T, Sugiyama T, Minamikawa T, Akazawa T (1966). "Enzymic mechanism of starch synthesis in ripening rice grains. 3 Mechanism of the sucrose-starch conversion". Arch. Biochem. Biophys. 113 (1): 34–44. doi:10.1016/0003-9861(66)90153-6. PMID 5941994. 
  • Yoshinaga F, Mori H, Sakai F, Hayashi T (1998). "An increase in apparent affinity for sucrose of mung bean sucrose synthase is caused by in vitro phosphorylation or directed mutagenesis of Ser11". Plant Cell Physiol. 39 (12): 1337–41. PMID 10050318. 
  • Porchia AC, Curatti L, Salerno GL (1999). "Sucrose metabolism in cyanobacteria: sucrose synthase from Anabaena sp. strain PCC 7119 is remarkably different from the plant enzymes with respect to substrate affinity and amino-terminal sequence". Planta. 210 (1): 34–40. doi:10.1007/s004250050651. PMID 10592030. 
  • Ross, HA, Davies HV (1992). "Purification and characterization of sucrose synthase from the cotyledons of Vicia fava L". Plant Physiol. 100 (2): 1008–1013. doi:10.1104/pp.100.2.1008. 
  • Silvius JE; Snyder FW (1979). "Comparative enzymic studies of sucrose metabolism in the taproots and fibrous roots of Beta vulgaris L". Plant Physiol. 64 (6): 1070–1073. doi:10.1104/pp.64.6.1070. 
  • Tanase K, Yamaki S (2000). "Purification and characterization of two sucrose synthase isoforms from Japanese pear fruit". Plant Cell Physiol. 41 (4): 408–14. doi:10.1093/pcp/41.4.408. PMID 10845453. 
  • T, Pozueta-Romero J; Muñoz, FJ; Saikusa, T; Rodríguez-López, M; Akazawa, T; Pozueta-Romero, J (2003). "Sucrose synthase catalyzes the de novo production of ADPglucose linked to starch biosynthesis in heterotrophic tissues of plants". Plant Cell Physiol. 44 (5): 500–9. doi:10.1093/pcp/pcg062. PMID 12773636.