Sulazepam

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Sulazepam
Sulazepam.svg
Clinical data
ATC code
  • none
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
Chemical and physical data
Formula C16H13ClN2S
Molar mass 300.81 g/mol
3D model (JSmol)
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Sulazepam is a benzodiazepine derivative. It is the thioamide derivative of diazepam. It is metabolised into diazepam, desmethyldiazepam and oxydiazepam[citation needed]. It has sedative, muscle relaxant, hypnotic, anticonvulsant and anxiolytic properties like those of other benzodiazepines.[1][2] It was never marketed.

Synthesis[edit]

Sulazepam synthesis:[3] U.S. Patent 3,141,890

Treatment of diazepam with phosphorus pentasulfide produces the corresponding thionamide, sulazepam.

See also[edit]

References[edit]

  1. ^ "sulazepam". psychotropics.dk. 2003. Retrieved 29 December 2008. 
  2. ^ Golovenko NIa, Zin'kovskii VG (September 1976). "(title in Russian)" [Analysis of the structure of the components of the convulsive action of corazole following administration of sulazepam and its metabolites to mice]. Biull Eksp Biol Med (in Russian). 82 (9): 1078–1081. PMID 11012. 
  3. ^ Archer, G. A.; Sternbach, L. H. (1964). "Quinazolines and 1,4-Benzodiazepines. XVI.1Synthesis and Transformations of 5-Phenyl-1,4-benzodiazepine-2-thiones". The Journal of Organic Chemistry. 29: 231. doi:10.1021/jo01024a511.