Sulbactam

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Sulbactam
Sulbactam.svg
Sulbactam ball-and-stick.png
Clinical data
AHFS/Drugs.com International Drug Names
MedlinePlus a693021
Routes of
administration
Injection
ATC code
Legal status
Legal status
  • UK: POM (Prescription only)
Pharmacokinetic data
Bioavailability 1
Excretion Kidneys?
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.063.506 Edit this at Wikidata
Chemical and physical data
Formula C8H11NO5S
Molar mass 233.243 g/mol
3D model (JSmol)
  (verify)

Sulbactam is a β-lactamase inhibitor. This drug is given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzyme produced by bacteria that destroys the antibiotics. [1]

Mechanism[edit]

Sulbactam is an irreversible inhibitor of β-lactamase; it binds to the enzyme and does not allow it to degrade the antibiotic.

Uses[edit]

Sulbactam is able to inhibit the most common forms of β-lactamase but is not able to interact with the AmpC cephalosporinase. Thus, it confers little protection against bacteria such as Pseudomonas aeruginosa, Citrobacter, Enterobacter, and Serratia, which often express this gene.

In the United States, sulbactam is combined to form ampicillin/sulbactam. It does possess some antibacterial activity when administered alone, but it is too weak to have any clinical importance. Its use in the UK is restricted to hospitals.

Recently, its use in treating Acinetobacter septicemia is receiving renewed interest.

See also[edit]

References[edit]

  1. ^ Totir MA, Helfand MS, Carey MP, et al. (August 2007). "Sulbactam forms only minimal amounts of irreversible acrylate-enzyme with SHV-1 beta-lactamase". Biochemistry. 46 (31): 8980–7. doi:10.1021/bi7006146. PMC 2596720Freely accessible. PMID 17630699. 

Further reading[edit]