Sulfadoxine

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Sulfadoxine
Sulfadoxine.svg
Sulfadoxine-3D-balls.png
Clinical data
AHFS/Drugs.com International Drug Names
ATCvet code
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
NIAID ChemDB
ECHA InfoCard 100.017.732 Edit this at Wikidata
Chemical and physical data
Formula C12H14N4O4S
Molar mass 310.33 g/mol
3D model (JSmol)
Melting point 190 to 194 °C (374 to 381 °F)
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Sulfadoxine (also spelled sulphadoxine) is an ultra-long-lasting sulfonamide used in combination with pyrimethamine to treat malaria.[1]

It was previously used to prevent malaria but due to high levels of resistance, this use is no longer recommended routinely.[2]

It is also used, usually in combination with other drugs, to treat or prevent various infections in livestock.[citation needed]

Mechanism of action[edit]

Sulfadoxine competitively inhibits dihydropteroate synthase, interfering with folate synthesis.

See also[edit]

References[edit]