|AHFS/Drugs.com||International Drug Names|
|Chemical and physical data|
|Molar mass||310.33 g/mol|
|3D model (JSmol)|
|Melting point||190 to 194 °C (374 to 381 °F)|
|(what is this?)|
It was previously used to prevent malaria but due to high levels of resistance, this use is no longer recommended routinely.
It is also used, usually in combination with other drugs, to treat or prevent various infections in livestock.
Mechanism of action
Sulfadoxine competitively inhibits dihydropteroate synthase, interfering with folate synthesis.
- Medical Treatment - Sulphadoxine and Pyrimethamine Archived 2007-12-28 at the Wayback Machine..
- Matondo SI, Temba GS, Kavishe AA, et al. (2014). "High levels of sulphadoxine-pyrimethamine resistance Pfdhfr-Pfdhps quintuple mutations: a cross sectional survey of six regions in Tanzania". Malar J. 13: 152. doi:10.1186/1475-2875-13-152. PMC . PMID 24751352.
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