Sulfadoxine

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Sulfadoxine
Sulfadoxine.svg
Sulfadoxine-3D-balls.png
Clinical data
AHFS/Drugs.com International Drug Names
ATCvet code QJ01EQ13 (WHO)
Identifiers
CAS Number 2447-57-6 YesY
PubChem (CID) 17134
DrugBank DB01299 N
ChemSpider 16218 N
UNII 88463U4SM5 N
KEGG D00580 YesY
ChEMBL CHEMBL1539 N
NIAID ChemDB 007816
ECHA InfoCard 100.017.732
Chemical and physical data
Formula C12H14N4O4S
Molar mass 310.33 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Sulfadoxine (also spelled sulphadoxine) is an ultra-long-lasting sulfonamide used in combination with pyrimethamine to treat malaria.[1]

It was previously used to prevent malaria but due to high levels of resistance, this use is no longer recommended routinely.[2]

It is also used, usually in combination with other drugs, to treat or prevent various infections in livestock.[citation needed]

Mechanism of action[edit]

Sulfadoxine competitively inhibits dihydropteroate synthase, interfering with folate synthesis.

See also[edit]

References[edit]