Sulfalene

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Sulfalene
Sulfalene2DCSD.svg
Clinical data
Trade namesEadazine, Kelfizina, Kelfizine W, Longum
SynonymsSulfametopyrazine
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Oral[1]
ATC code
Pharmacokinetic data
Protein binding60 to 80%[1]
Elimination half-life60 to 65 hours[1]
ExcretionUrinary[1]
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.005.278 Edit this at Wikidata
Chemical and physical data
FormulaC11H12N4O3S
Molar mass280.304 g/mol g·mol−1
3D model (JSmol)
  (verify)

Sulfalene (INN, USAN) or sulfametopyrazine (BAN) is a long-acting sulfonamide antibacterial used for the treatment of chronic bronchitis, urinary tract infections and malaria.[2][3] As of 2014 there were only two countries in which it is currently still marketed: Thailand and Ireland.[3]

It was discovered by researchers at Farmitalia and first published in 1960 and was marketed as Kelfizina.[4][5]

See also[edit]

References[edit]

  1. ^ a b c d "Sulfalene". MIMS Drug Information System. Retrieved 26 August 2011.
  2. ^ DrugBank DB00664
  3. ^ a b Brayfield, A, ed. (9 May 2013). "Sulfametopyrazine". Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 28 March 2014.
  4. ^ Baruffa G. Clinical trials in Plasmodium falciparum malaria with a long-acting sulphonamide. Trans R Soc Trop Med Hyg. 1966;60(2):222-4. PMID 5332105
  5. ^ Per prior citation, the first publication: Camerino B, Palamidessi G (1960) Derivati della parazina II. Sulfonamdopir (in Italian). Gazz Chim Ital 90:1802–1815