Sulfalene

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Sulfalene
Sulfalene2DCSD.svg
Systematic (IUPAC) name
4-Amino-N-(3-methoxypyrazinyl)benzenesulfonamide
Clinical data
Trade names Eadazine, Kelfizina, Kelfizine W, Longum
AHFS/Drugs.com International Drug Names
Routes of
administration
Oral[1]
Pharmacokinetic data
Protein binding 60 to 80%[1]
Biological half-life 60 to 65 hours[1]
Excretion Urinary[1]
Identifiers
CAS Number 152-47-6 YesY
ATC code J01ED02 (WHO) QJ01EQ19 (WHO)
PubChem CID 9047
DrugBank DB00664 YesY
ChemSpider 8695 YesY
UNII T6BL4ZC15G YesY
KEGG D01216 YesY
Synonyms Sulfametopyrazine
Chemical data
Formula C11H12N4O3S
Molar mass 280.304 g/mol
  (verify)

Sulfalene (INN, USAN) or sulfametopyrazine (BAN) is a long-acting sulfonamide antibacterial used for the treatment of chronic bronchitis, urinary tract infections and malaria.[2][3] As of 2014 there were only two countries in which it is currently still marketed: Thailand and Ireland.[3]

It was discovered by researchers at Farmitalia and first published in 1960 and was marketed as Kelfizina.[4][5]

See also[edit]

References[edit]

  1. ^ a b c d "Sulfalene". MIMS Drug Information System. Retrieved 26 August 2011. 
  2. ^ DrugBank DB00664
  3. ^ a b Brayfield, A, ed. (9 May 2013). "Sulfametopyrazine". Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 28 March 2014. 
  4. ^ Baruffa G. Clinical trials in Plasmodium falciparum malaria with a long-acting sulphonamide. Trans R Soc Trop Med Hyg. 1966;60(2):222-4. PMID 5332105
  5. ^ Per prior citation, the first publication: Camerino B, Palamidessi G (1960) Derivati della parazina II. Sulfonamdopir (in Italian). Gazz Chim Ital 90:1802–1815