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Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
ATCvet code
Pharmacokinetic data
BioavailabilityVery low
ExcretionRenal, unchanged
  • N,N,N′,N′-tetraethyldicarbonotrithioic diamide
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.002.171 Edit this at Wikidata
Chemical and physical data
Molar mass264.46 g·mol−1

Sulfiram (INN) or monosulfiram, trade name Tetmosol, is an ectoparasiticide used in the treatment and prevention of scabies.[1] It is usually sold as a solution or medicated soap, sometimes in combination with benzyl benzoate.

Sulfiram is now rarely used, but, as of 2015, is still available in Brazil, India, and South Africa (as monotherapy).[1]

Adverse effects[edit]

Dizziness, headache, fatigue and erythematous rash may occur.[2] A single case of toxic epidermal necrolysis was reported in 1968.[3]

Sulfiram is structurally related to disulfiram (Antabuse), and readily converts to disulfiram when exposed to light. Like disulfiram, it can produce an unpleasant reaction when consumed with alcohol.[1][4]


  1. ^ a b c Sweetman, Sean C., ed. (2009). "Pesticides and repellents". Martindale: the complete drug reference (36th ed.). London: Pharmaceutical Press. p. 2050. ISBN 978-0-85369-840-1.
  2. ^ [No authors listed] (2009). "Sarfiram - Bula". Bulário de Remédios Comerciais (in Portuguese). MedicinaNET. Retrieved 2010-08-11.
  3. ^ Copeman PW (March 1968). "Toxic epidermal necrolysis caused by skin hypersensitivity to monosulfiram". British Medical Journal. 1 (5592): 623–4. doi:10.1136/bmj.1.5592.623. PMC 1985336. PMID 5637574.
  4. ^ Mays DC, Nelson AN, Benson LM, Johnson KL, Naylor S, Lipsky JJ (November 1994). "Photolysis of sulfiram: a mechanism for its disulfiram-like reaction". Biochemical Pharmacology. 48 (10): 1917–25. doi:10.1016/0006-2952(94)90590-8. PMID 7986203.

External links[edit]