Sulfite reductase (NADPH)

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Sulfite reductase (NADPH)
EC number1.8.1.2
CAS number9029-35-0
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum

Sulfite reductase (NADPH) (EC, sulfite (reduced nicotinamide adenine dinucleotide phosphate) reductase, NADPH-sulfite reductase, NADPH-dependent sulfite reductase, H2S-NADP oxidoreductase, sulfite reductase (NADPH2)) is an enzyme with systematic name hydrogen-sulfide:NADP+ oxidoreductase.[1][2][3] This enzyme catalises the following chemical reaction

hydrogen sulfide + 3 NADP+ + 3 H2O sulfite + 3 NADPH + 3 H+

Sulfite reductase is an iron flavoprotein (FAD and FMN).


  1. ^ Hilz H, Kittler M, Knape G (1959). "[The reduction of sulfate in yeast]". Biochemische Zeitschrift. 332: 151–66. PMID 14401842.
  2. ^ Siegel LM, Murphy MJ, Kamin H (January 1973). "Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. I. The Escherichia coli hemoflavoprotein: molecular parameters and prosthetic groups". The Journal of Biological Chemistry. 248 (1): 251–64. PMID 4144254.
  3. ^ Yoshimoto A, Sato R (April 1968). "Studies on yeast sulfite reductase. I. Purification and characterization". Biochimica et Biophysica Acta. 153 (3): 555–75. doi:10.1016/0005-2728(68)90185-0. PMID 4384979.

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