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IUPAC name
4478-93-7 YesY
3D model (Jmol) Interactive image
ChemSpider 5157 N
PubChem 5350
Molar mass 177.29 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Sulforaphane is a compound within the isothiocyanate group of organosulfur compounds. It is obtained from cruciferous vegetables such as broccoli, Brussels sprouts or cabbages. It is produced when the enzyme myrosinase transforms glucoraphanin, a glucosinolate, into sulforaphane upon damage to the plant (such as from chewing), which allows the two compounds to mix and react. Young sprouts of broccoli and cauliflower are particularly rich in glucoraphanin.

glucoraphanin, glucosinolate precursor to sulforaphane

Occurrence and isolation[edit]

Sulforaphane was identified in broccoli sprouts, which, of the cruciferous vegetables, have the highest concentration of sulforaphane.[1] It is also found in Brussels sprout, cabbage, cauliflower, bok choy, kale, collards, Chinese broccoli, broccoli raab, kohlrabi, mustard, turnip, radish, arugula, and watercress.


Basic research on sulforaphane includes how it may affect neurodegenerative disorders, cancer or gastric diseases,[2][3][4] and preliminary human research on autism.[5]

See also[edit]


  1. ^ Zhang Y, Talalay P, Cho CG, Posner GH (March 1992). "A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure". Proc. Natl. Acad. Sci. U.S.A. 89 (6): 2399–2403. doi:10.1073/pnas.89.6.2399. PMC 48665Freely accessible. PMID 1549603. 
  2. ^ Tarozzi A, Angeloni C, Malaguti M, Morroni F, Hrelia S, Hrelia P (2013). "Sulforaphane as a potential protective phytochemical against neurodegenerative diseases". Oxid Med Cell Longev (Review). 2013: 415078. doi:10.1155/2013/415078. PMC 3745957Freely accessible. PMID 23983898. 
  3. ^ Grabacka MM, Gawin M, Pierzchalska M (2014). "Phytochemical modulators of mitochondria: the search for chemopreventive agents and supportive therapeutics". Pharmaceuticals (Basel) (Review). 7 (9): 913–42. doi:10.3390/ph7090913. PMC 4190497Freely accessible. PMID 25192192. 
  4. ^ Moon JK, Kim JR, Ahn YJ, Shibamoto T (2010). "Analysis and anti-Helicobacter activity of sulforaphane and related compounds present in broccoli ( Brassica oleracea L.) sprouts". J. Agric. Food Chem. 58 (11): 6672–7. doi:10.1021/jf1003573. PMID 20459098. 
  5. ^ Singh, Kanwaljit; Connors, Susan L.; Macklin, Eric A.; Smith, Kirby D.; Fahey, Jed W.; Talalay, Paul; Zimmerman, Andrew W. (28 October 2014). "Sulforaphane treatment of autism spectrum disorder (ASD)". Proceedings of the National Academy of Sciences. 111 (43): 15550–15555. doi:10.1073/pnas.1416940111. ISSN 0027-8424. PMC 4217462Freely accessible. PMID 25313065.