Sulforhodamine 101

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Sulforhodamine 101
Sulforhodamine 101 structure.png
3D model (JSmol)
ECHA InfoCard 100.056.491
Molar mass 606.71 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Sulforhodamine 101 (SR101) is a red fluorescent dye. In neurophysiological experiments which comprise calcium imaging methods, it can be used for a counterstaining of astrocytes to be able to analyze data from neurons separately.[1] However, in addition to labeling astrocytes, SR101 labels myelinating oligodendrocytes.[2] SR101 has been reported to affect excitability of neurons and should therefore be used with caution.[3]

A sulfonyl chloride derivative of sulforhodamine 101, known as Texas Red, is used for conjugation to a number of functional groups, especially primary amines.


  1. ^ Nimmerjahn, A.; Kirchhoff, F.; Kerr, J.N.; Helmchen, F. (2004). "Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo". Nature Methods. 1 (1): 31–7. PMID 15782150. doi:10.1038/nmeth706. closed access publication – behind paywall
  2. ^ Hill, R.A.; Grutzendler, J. (2014). "In vivo imaging of oligodendrocytes with sulforhodamine 101". Nature Methods. 11 (11): 1081–1082. PMC 4539948Freely accessible. PMID 25357236. doi:10.1038/nmeth.3140. closed access publication – behind paywall
  3. ^ Kang, J.; Kang N.; Yu, Y.; Zhang, J.; et al. (2010). "Sulforhodamine 101 induces long-tem potentiation of intrinsic excitability and synaptic efficacy in hippocampal CA1 pyramidal neurons". Neuroscience. 169 (4): 1601–1609. PMC 2918738Freely accessible. PMID 20600669. doi:10.1016/j.neuroscience.2010.06.020.