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Clinical data
AHFS/ Micromedex Detailed Consumer Information
MedlinePlus a682204
ATC code
CAS Number
PubChem CID
ECHA InfoCard 100.005.130 Edit this at Wikidata
Chemical and physical data
Formula C11H11N3O2S
Molar mass 249.29 g/mol
3D model (JSmol)
 NYesY (what is this?)  (verify)

Sulfapyridine (INN; also known as sulphapyridine) is a sulfonamide antibacterial medication. At one time it was commonly referred to as M&B. Sulfapyridine is no longer prescribed for treatment of infections in humans. However, it may be used to treat linear IgA disease and has use in veterinary medicine.[1] It is a good antibacterial drug, but its water solubility is very pH dependent. Thus there is a risk of crystallization within the bladder or urethra, which could lead to pain or blockage. As with other sulfonamides, there is a significant risk of agranulocytosis, and this, rather than the development of resistance by bacteria, is the main reason for its decline in use.


M&B 693 was one of the first generation of sulfonamide antibiotics. It was discovered by Lionel Whitby at the British firm May & Baker Ltd and logged in their Test Book on 2 November, 1937 under Code No M&B 693.[2] It could either be taken in tablet form or the powder could be placed in wounds. It was used so widely during the Second World War that May & Baker had difficulty keeping up with demand. It was later largely superseded by penicillin and other sulfonamides.

Related medications[edit]

The drug sulfasalazine is structurally one molecule of mesalamine linked to one molecule of sulfapyridine with an azo chemical linker.


  1. ^ "Sulfapyride". 
  2. ^ Lesch, John (2007). "Chapter 7". The First Miracle Drugs (illustrated ed.). Oxford University Press. ISBN 0-19-518775-X.