|Superior oblique myokymia|
|6 = Superior oblique muscle|
It is a condition that presents as repeated, brief episodes of movement, shimmering or shaking of the vision of one eye, a feeling of the eye trembling, or vertical/tilted vision. It can present as one or more of these symptoms. Diagnosis is most often made by the elimination of other conditions, disorders or diseases. Onset usually occurs in adulthood, and the cause is benign and is not commonly associated with other disorders.
In 1983, Bringewald postulated that superior oblique myokymia resulted from vascular compression of the trochlear nerve (fourth cranial nerve), which controls the action of the superior oblique muscle in the eye. By 1998, there had been only one reported case of compression of the trochlear nerve by vessels. More recently, magnetic resonance imaging experiments have shown that neurovascular compression at the root exit zone of the trochlear nerve can result in superior oblique myokymia.
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Treatment can include pharmaceutical or surgical means. The drug carbamazepine (Tegretol) has been used successfully. Other drugs with variable success include gabapentin and, recently,[when?] memantine. Successful surgery options include superior oblique tenectomy accompanied by inferior oblique myectomy. However, "[o]verall, the bulk of the ophthalmic literature would agree with the viewpoint that invasive craniotomy surgical procedures should be justified only by the presence of intractable and absolutely unbearable symptoms."
Samii et al. and Scharwey and Samii described a patient who had superior oblique myokymia for 17 years. The interposition of a Teflon pad between the trochlear nerve and a compressing artery and vein at the nerve's exit from the midbrain led to a remission lasting for a follow-up of 22 months.
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- Bringewald PR (August 1983). "Superior oblique myokymia". Arch. Neurol. 40 (8): 526. doi:10.1001/archneur.1983.04210070066021. PMID 6870617.
- Samii M, Rosahl SK, Carvalho GA, Krzizok T (1998). "Microvascular decompression for superior oblique myokymia: first experience. Case report". J. Neurosurg. 89 (6): 1020–24. doi:10.3171/jns.19188.8.131.520. PMID 9833830.
- Scharwey K, Krzizok T, Samii M, Rosahl SK, Kaufmann H (2000). "Remission of superior oblique myokymia after microvascular decompression". Ophthalmologica. 214 (6): 426–28. doi:10.1159/000027537. PMID 11054004. S2CID 35862822.
- Yousry I, Dieterich M, Naidich TP, Schmid UD, Yousry TA (March 2002). "Superior oblique myokymia: magnetic resonance imaging support for the neurovascular compression hypothesis". Ann. Neurol. 51 (3): 361–68. doi:10.1002/ana.10118. PMID 11891831. S2CID 23905926.
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