Surfactant protein C

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Surfactant protein C, N terminal propeptide
1spf opm.png
Pulmonary surfactant-associated polypeptide SP-C Protein
Symbol SP_C-Propep
Pfam PF08999
InterPro IPR001729
OPM superfamily 75
OPM protein 1spf
surfactant, pulmonary-associated protein C
Symbol SFTPC
Alt. symbols SFTP2
Entrez 6440
HUGO 10802
OMIM 178620
RefSeq NM_003018
UniProt P11686
Other data
Locus Chr. 8 p21

Surfactant proteins C are a family of related pulmonary surfactant proteins.

The propeptide of human protein from this family has an N-terminal alpha-helical segment whose suggested function was stabilization of the protein structure, since the latter can irreversibly transform from its native alpha-helical structure to beta-sheet aggregates and form amyloid fibrils. The correct intracellular trafficking of proSP-C has also been reported to depend on the propeptide.[1]


  1. ^ Li J, Liepinsh E, Almlén A, Thyberg J, Curstedt T, Jörnvall H, Johansson J (March 2006). "Structure and influence on stability and activity of the N-terminal propeptide part of lung surfactant protein C". FEBS J. 273 (5): 926–35. doi:10.1111/j.1742-4658.2006.05124.x. PMID 16478467. 

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This article incorporates text from the public domain Pfam and InterPro IPR015091