The wealthy and prominent Beirut aristocrat Nicolas Ibrahim Sursock built the private villa that now houses the museum in 1912. He decreed in his will that the villa be transformed into a museum and when he died in 1952 he bequeathed the villa to the city of Beirut. The museum opened its doors in 1961 directed by Ibrahim M. Beyhum with an exhibit of works of contemporary Lebanese artists, setting a precedent for cultural events in Beirut.
The Sursock Museum building exemplifies Lebanese architecture with its Italianate, specifically Venetian, and Ottoman architectural influences.  It is located in the historic Rue Sursock street in the Achrafieh district of Beirut. The street is home to other mansions that were built in the 19th century by Beirut's most prominent families such as the Sursocks and the Bustroses.
More than a hundred exhibitions have been held at the museum displays including works of Lebanese and international artists. The museum's permanent collection includes modern art, Japanese engravings and Islamic art. The museum collection consists of over 800 artworks, including paintings, sculptures, and graphic arts from the 19th and 20th centuries.
The museum was expanded with four new underground floors beneath the current garden at a cost of 12 million dollars (US). French architect Jean-Michel Wilmotte and Lebanese architect Jacques Abou Khaled designed the expansion project. The project will increase the museum’s area from 1,500 square meters to 8,500 square meters and open additional exhibition spaces, a research library, an auditorium, a restoration workshop, new storage spaces for the collection, as well as a store and restaurant. The museum reopened its doors on October 8, 2015.
The following is a list of Lebanese and international artists whose work is in the Museum’s permanent collection:
- Guides.hotelbook.com, Events Guide: Sursock Museum (Sursock Museum, Beirut, Lebanon)
- Galleries Beirut, Sursock museum, Georges Guv Aref Rayess, John Haddian, Levon Moumjian. Madi Hussein