Survival of motor neuron protein-interacting protein 1

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Gem (nuclear organelle) associated protein 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols GEMIN2 ; SIP1; SIP1-delta
External IDs OMIM602595 MGI1913853 HomoloGene37827 GeneCards: GEMIN2 Gene
RNA expression pattern
PBB GE SIP1 205063 at tn.png
PBB GE SIP1 210779 x at tn.png
PBB GE SIP1 211114 x at tn.png
More reference expression data
Species Human Mouse
Entrez 8487 66603
Ensembl ENSG00000092208 ENSMUSG00000060121
UniProt O14893 Q9CQQ4
RefSeq (mRNA) NM_001009182 NM_025656
RefSeq (protein) NP_001009182 NP_079932
Location (UCSC) Chr 14:
39.11 – 39.14 Mb
Chr 12:
59.01 – 59.03 Mb
PubMed search [1] [2]

Survival of motor neuron protein-interacting protein 1 is a protein that in humans is encoded by the SIP1 gene.[1][2][3]


Survival of motor neuron protein-interacting protein 1 has been shown to interact with DDX20[4][5] and SMN1.[2][6][7]

See also[edit]


  1. ^ Fischer U, Liu Q, Dreyfuss G (October 1997). "The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis". Cell 90 (6): 1023–9. doi:10.1016/S0092-8674(00)80368-2. PMID 9323130. 
  2. ^ a b Liu Q, Fischer U, Wang F, Dreyfuss G (October 1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell 90 (6): 1013–21. doi:10.1016/S0092-8674(00)80367-0. PMID 9323129. 
  3. ^ "Entrez Gene: SIP1 survival of motor neuron protein interacting protein 1". 
  4. ^ Mourelatos, Zissimos; Dostie Josée; Paushkin Sergey; Sharma Anup; Charroux Bernard; Abel Linda; Rappsilber Juri; Mann Matthias; Dreyfuss Gideon (March 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. (United States) 16 (6): 720–8. doi:10.1101/gad.974702. ISSN 0890-9369. PMC 155365. PMID 11914277. 
  5. ^ Charroux, B; Pellizzoni L; Perkinson R A; Shevchenko A; Mann M; Dreyfuss G (December 1999). "Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems". J. Cell Biol. (UNITED STATES) 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. ISSN 0021-9525. PMC 2168095. PMID 10601333. 
  6. ^ Carnegie, Graeme K; Sleeman Judith E; Morrice Nick; Hastie C James; Peggie Mark W; Philp Amanda; Lamond Angus I; Cohen Patricia T W (May 2003). "Protein phosphatase 4 interacts with the Survival of motor neurons complex and enhances the temporal localisation of snRNPs". J. Cell. Sci. (England) 116 (Pt 10): 1905–13. doi:10.1242/jcs.00409. ISSN 0021-9533. PMID 12668731. 
  7. ^ Meister, G; Bühler D; Laggerbauer B; Zobawa M; Lottspeich F; Fischer U (August 2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins". Hum. Mol. Genet. (ENGLAND) 9 (13): 1977–86. doi:10.1093/hmg/9.13.1977. ISSN 0964-6906. PMID 10942426. 

Further reading[edit]