|Born||20 December 1797|
|Died||8 December 1877 (aged 79)|
Tunbridge Wells, Kent
|Awards||RIBA Royal Gold Medal|
|Buildings||The circular reading room at the British Museum|
Smirke who was born in London, England, the fifth son of painter Robert Smirke and his wife, Elizabeth Russell. He was the younger brother of Sir Robert Smirke and Sir Edward Smirke, also an architect.
He received the RIBA Royal Gold Medal in 1860. He became an associate of the Royal Academy in 1847 and was elected a full Academician in 1859. He served as RA Treasurer from 1861 to 1874, and was professor of Architecture from 1860 to 1865.
Among Smirke's numerous apprentices was the successful York architect George Fowler Jones.
Sydney Smirke's works include:
- Customs House (refronting), Quayside, Newcastle upon Tyne, (1833)
- The Custom House, Queen Square, Bristol (1835–57)
- Wellington Pit Surface Buildings (Whitehaven) (1840)
- The nave roof of York Minster (1841)
- Holy Trinity Church, Bickerstaffe, Lancashire (1843)
- The Carlton Club in Pall Mall, London (1845)
- The Custom House, Commercial Road, Gloucester (1845)
- The dome chapel of the Bethlem Royal Hospital, St George's Fields, Southwark (now housing the Imperial War Museum) (1846)
- The Frewen Mausoleum at St Mary's Church, Northiam, East Sussex (1846)
- St. James' Church, Westhead, Lancashire (1850)
- St Mary the Virgin's Church, Theydon Bois (1850)
- The Derby Hall, Derby Hotel and Athenaeum in Bury (1849–52; the latter two now demolished)
- The circular reading room at the British Museum (1857)
- King Edward's School, Witley, Surrey (1865)
- Exhibition galleries at Burlington House, home o the Royal Academy (1868)
- Hall of Inner Temple (1870)
- St John's Church, Loughton
- Landscaping of Brookwood Cemetery, near Woking, Surrey (with William Tite)
- Toll House, Lower Sandgate Road, Folkestone 
- England, Select Births and Christenings, 1538-1975
- Historic England. "Parish Church of St Mary (1337290)". National Heritage List for England. Retrieved 1 February 2016.
- "Toll House – Lower Sandgate Road – Folkestone, Kent UK". www.waymarking.com. 4 January 2012. Retrieved 22 December 2013.
- Fawcett, Jane (Editor), Seven Victorian Architects, Thames and Hudson, 1976. ISBN 0-500-34070-6
- Gentleman's Magazine, 1841, Part 1, p91
- Oxford Dictionary of National Biography