Syntaxin binding protein 3

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Syntaxin binding protein 3
Protein STXBP3 PDB 2pjx.png
PDB rendering based on 2pjx.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols STXBP3 ; MUNC18-3; MUNC18C; PSP; UNC-18C
External IDs OMIM608339 MGI107362 HomoloGene5260 GeneCards: STXBP3 Gene
RNA expression pattern
PBB GE STXBP3 203310 at tn.png
More reference expression data
Species Human Mouse
Entrez 6814 20912
Ensembl ENSG00000116266 ENSMUSG00000027882
UniProt O00186 Q60770
RefSeq (mRNA) NM_007269 NM_011504
RefSeq (protein) NP_009200 NP_035634
Location (UCSC) Chr 1:
108.75 – 108.81 Mb
Chr 3:
108.79 – 108.84 Mb
PubMed search [1] [2]

Syntaxin-binding protein 3 is a protein that in humans is encoded by the STXBP3 gene.[1][2]


Syntaxin binding protein 3 has been shown to interact with STX2[3] and STX4.[3][4]


  1. ^ Reed GL, Houng AK, Fitzgerald ML (May 1999). "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion". Blood 93 (8): 2617–26. PMID 10194441. 
  2. ^ "Entrez Gene: STXBP3 syntaxin binding protein 3". 
  3. ^ a b Schraw, Todd D; Lemons Paula P; Dean William L; Whiteheart Sidney W (Aug 2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". Biochem. J. (England) 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. ISSN 0264-6021. PMC 1223584. PMID 12773094. 
  4. ^ Widberg, Charlotte H; Bryant Nia J; Girotti Milena; Rea Shane; James David E (Sep 2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". J. Biol. Chem. (United States) 278 (37): 35093–101. doi:10.1074/jbc.M304261200. ISSN 0021-9258. PMID 12832401. 

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