Synthetic Biology Open Language

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The Synthetic Biology Open Language (SBOL)[1] is a proposed data standard for exchanging synthetic biology designs between software packages.[2] It has been under development by the SBOL Developers Group[3] since 2008. This group aims to develop the standard in a way that is open and democratic in order to include as many interests as possible and to avoid domination by a single company. The group also aims to develop and improve the design standard over time as the field of synthetic biology reflects this development.

A graphical modeling language called SBOL visual has also been created to visualize SBOL designs.[4]

Synthetic Biology Open Language (SBOL) standard visual symbols: promoter, primer binding site, cds, restriction site, etc.


Version Date
1.0 November 2011
1.1 October 2012
2.0 July 2015
2.1.0 October 2016[5]


  1. ^ "The Synthetic Biology Open Language (SBOL)".
  2. ^ Galdzicki, Michal; Clancy, Kevin P; Oberortner, Ernst; Pocock, Matthew; Quinn, Jacqueline Y; Rodriguez, Cesar A; Roehner, Nicholas; Wilson, Mandy L; Adam, Laura; Anderson, J Christopher; Bartley, Bryan A; Beal, Jacob; Chandran, Deepak; Chen, Joanna; Densmore, Douglas; Endy, Drew; Grünberg, Raik; Hallinan, Jennifer; Hillson, Nathan J; Johnson, Jeffrey D; Kuchinsky, Allan; Lux, Matthew; Misirli, Goksel; Peccoud, Jean; Plahar, Hector A; Sirin, Evren; Stan, Guy-Bart; Villalobos, Alan; Wipat, Anil; Gennari, John H; Myers, Chris J; Sauro, Herbert M (6 June 2014). "The Synthetic Biology Open Language (SBOL) provides a community standard for communicating designs in synthetic biology". Nature Biotechnology. 32 (6): 545–550. doi:10.1038/nbt.2891. PMID 24911500.
  3. ^
  4. ^ Quinn, Jacqueline Y.; Cox, Robert Sidney; Adler, Aaron; Beal, Jacob; Bhatia, Swapnil; Cai, Yizhi; Chen, Joanna; Clancy, Kevin; Galdzicki, Michal; Hillson, Nathan J.; Le Novère, Nicolas; Maheshwari, Akshay J.; McLaughlin, James Alastair; Myers, Chris J.; P, Umesh; Pocock, Matthew; Rodriguez, Cesar; Soldatova, Larisa; Stan, Guy-Bart V.; Swainston, Neil; Wipat, Anil; Sauro, Herbert M. (3 December 2015). "SBOL Visual: A Graphical Language for Genetic Designs". PLOS Biology. 13 (12): e1002310. doi:10.1371/journal.pbio.1002310. PMC 4669170. PMID 26633141.
  5. ^ Beal, Jacob; Cox, Robert Sidney; Grünberg, Raik; McLaughlin, James; Nguyen, Tramy; Bartley, Bryan; Bissell, Michael; Choi, Kiri; Clancy, Kevin; MacKlin, Chris; Madsen, Curtis; Misirli, Goksel; Oberortner, Ernst; Pocock, Matthew; Roehner, Nicholas; Samineni, Meher; Zhang, Michael; Zhang, Zhen; Zundel, Zach; Gennari, John H.; Myers, Chris; Sauro, Herbert; Wipat, Anil (2016). "Synthetic Biology Open Language (SBOL) Version 2.1.0". Journal of Integrative Bioinformatics. 13 (3): 291. doi:10.1515/jib-2016-291. PMID 28187407.