Having formed in 2010 with the intention of playing in the new I-League (a United Soccer Leagues league set to begin play in 2011), the team moved to the Major Indoor Soccer League when the two leagues merged. The team was rumored to be named the Syracuse Scorpions and revive the name of an old American Soccer League team. However, the name Silver Knights was announced at the team's inaugural press conference. The club is coached by former Silver Knights goalkeeper, Bryan O'Quinn, who replaced club President, Team Owner and Syracuse native Tommy Tanner for the 2016-17 season. The club has signed former Syracuse Salty Dogs player Ryan Hall, among others. The team announced the signing of former Major League Soccer star Diego Serna on October 11, 2011.
The Syracuse Silver Knights' first season of play began in 2011–12, when they joined the MISL as an expansion franchise. For their inaugural season, the Silver Knights played their home games at the Oncenter War Memorial Arena in downtownSyracuse.
The team finished third in the Eastern Division in 2012, having been eliminated from playoff contention when the Rochester Lancers beat the Wichita Wings on February 23, 2012.
In 2013, the Silver Knight foundation was launched to help benefit kids in tough economic and social situations. The foundation hosts events throughout the year which helps raise money for these children. Many Silver Knights players, including reserve and U19 players, volunteer their time to help partake in the events.
After the 2013-2014 season, the team announced that it was leaving the MISL along with five other teams and join the PASL, which was subsequently renamed the MASL
The Silver Knights also have a U19/Academy team. Local youth team CNY United was granted rights to use the name "Syracuse Silver Knights U19" by Head Coach Tommy Tanner in 2013. They are coached by Silver Knights assistant coach Joe Papaleo and Silver Knights first team player LJ Papaleo. The players often help with fundraising and charity events along with the First Team players and staff