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Syrus is a character in Greek mythology after whom Syria and the Syrians are named.
Syrus may also refer to:
- Publilius Syrus (fl. 85 BC - 43 BC), Syrian-born Latin writer best known for his sententiae
- Syrus of Pavia (fl. 1st century AD), bishop and saint
- Ephrem the Syrian (c. 306 – 373), Syriac Christian deacon and Syriac-language hymnographer and theologian
- Syrus of Genoa (died 381), bishop and saint
- Syrus Truesdale, a character in the Yu-Gi-Oh! GX anime series