Systems medicine

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Systems medicine is an interdisciplinary field of study that looks at the systems of the human body as part of an integrated whole, incorporating biochemical, physiological, and environment interactions. Systems medicine draws on systems science and systems biology, and considers complex interactions within the human body in light of a patient's genomics, behavior and environment.[1]

The earliest uses of the term systems medicine appeared in 1992, in an article on systems medicine and pharmacology by B.J. Zeng [2] ( termed "systems medicine and pharmacology").[3]

An important topic in systems medicine and systems biomedicine is the development of computational models that describe disease progression and the effect of therapeutic interventions.[4] [5]

More recent approaches include the redefinition of disease phenotypes based on common mechanisms rather than symptoms. These provide then therapeutic targets including network pharmacology[6] and drug repurposing.[7] Since 2018, there is a dedicated scientific journal, Systems Medicine.[8]

List of research groups[edit]

Country University / Institute Department / Center / Program / Network Participants
Ireland Royal College of Surgeons in Ireland Medical Systems Biology[9]
Luxembourg Luxembourg Centre for Systems Biomedicine Computational Biology group[10]
Netherlands Eindhoven University of Technology (TU/e) Department of Biomedical Engineering, Computational Biology Group (CBio)[11] Natal van Riel, Peter Hilbers
USA Institute for Systems Biology (ISB) Leroy Hood, Alan Aderem, Ruedi Aebersold
Germany Helmholtz Association of German Research Centres Department of Systems Immunology[12] Esteban Hernandez-Vargas
Netherlands Utrecht University

University Medical Center Utrecht

Maastricht University

Laboratory of Translational Immunology[13]

Utrecht Center for Quantitative Immunology[14]

Pharmacology and Personalised Medicine[15]

Prof. Timothy Radstake,

Dr. Aridaman Pandit

Prof. Harald H.H.W. Schmidt

Israel Weizmann Institute of Science Department of Molecular Cell Biology[16]

Systems Medicine course[17]

Uri Alon[18][19]

References[edit]

  1. ^ Federoff HJ, Gostin LO (September 2009). "Evolving from reductionism to holism: is there a future for systems medicine?". JAMA. 302 (9): 994–6. doi:10.1001/jama.2009.1264. PMID 19724047.
  2. ^ Zeng BZ (April 1992). On the holographic model of human body. 1st National Conference of Comparative Studies Traditional Chinese Medicine and West Medicine (Medicine and Philosophy. Guangzhou.
  3. ^ Kamada T (1992). "System biomedicine: a new paradigm in biomedical engineering". Frontiers of Medical and Biological Engineering. 4 (1): 1–2. PMID 1599879.
  4. ^ de Winter W, DeJongh J, Post T, Ploeger B, Urquhart R, Moules I, Eckland D, Danhof M (June 2006). "A mechanism-based disease progression model for comparison of long-term effects of pioglitazone, metformin and gliclazide on disease processes underlying Type 2 Diabetes Mellitus". Journal of Pharmacokinetics and Pharmacodynamics. 33 (3): 313–43. doi:10.1007/s10928-006-9008-2. PMID 16552630.
  5. ^ Tiemann CA, Vanlier J, Oosterveer MH, Groen AK, Hilbers PA, van Riel NA (Aug 2013). "Parameter trajectory analysis to identify treatment effects of pharmacological interventions". PLoS Computational Biology. 9 (8): e1003166. Bibcode:2013PLSCB...9E3166T. doi:10.1371/journal.pcbi.1003166. PMC 3731221. PMID 23935478.
  6. ^ Oettrich JM, Dao VT, Frijhoff J, Kleikers P, Casas AI, Hobbs AJ, Schmidt HH (April 2016). "Clinical relevance of cyclic GMP modulators: A translational success story of network pharmacology". Clinical Pharmacology and Therapeutics. 99 (4): 360–2. doi:10.1002/cpt.336. PMID 26765222.
  7. ^ Langhauser F, Casas AI, Dao VT, Guney E, Menche J, Geuss E, Kleikers PW, López MG, Barabási AL, Kleinschnitz C, Schmidt HH (2018-02-05). "A diseasome cluster-based drug repurposing of soluble guanylate cyclase activators from smooth muscle relaxation to direct neuroprotection". NPJ Systems Biology and Applications. 4 (1): 8. doi:10.1038/s41540-017-0039-7. PMC 5799370. PMID 29423274.
  8. ^ Baumbach J, Schmidt HH (2018). "The End of Medicine as We Know It: Introduction to the New Journal, Systems Medicine". Systems Medicine. 1: 1–2. doi:10.1089/sysm.2017.28999.jba.
  9. ^ "Medical Systems Biology". Royal College of Surgeons in Ireland.
  10. ^ "Computational Biology group". Luxembourg Centre for Systems Biomedicine.
  11. ^ "Computational Biology Group". Eindhoven University of Technology.
  12. ^ "Systems Biology at the Helmholtz Centre for Infectious Diseases, Braunschweig". Helmholtz Centre for Infection Research.
  13. ^ "Radstake TRDJ".
  14. ^ "Utrecht Center for Quantitative Immunology".
  15. ^ "Pharmacology & Personalised Medicine | Pharmacology & Personalised Medicine". ppm.mumc.maastrichtuniversity.nl. Retrieved 2017-02-02.
  16. ^ "Molecular Cell Biology, Weizmann Institute of Science". www.weizmann.ac.il. Retrieved 2019-05-05.
  17. ^ "Systems Medicine course 2019 | Uri Alon". www.weizmann.ac.il. Retrieved 2019-05-05.
  18. ^ Karin O, Swisa A, Glaser B, Dor Y, Alon U (November 2016). "Dynamical compensation in physiological circuits". Molecular Systems Biology. 12 (11): 886. doi:10.15252/msb.20167216. PMC 5147051. PMID 27875241.
  19. ^ Karin O, Alon U (June 2017). "Biphasic response as a mechanism against mutant takeover in tissue homeostasis circuits". Molecular Systems Biology. 13 (6): 933. doi:10.15252/msb.20177599. PMC 5488663. PMID 28652282.