Systems medicine

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Systems medicine is an interdisciplinary field of study that looks at the systems of the human body as part of an integrated whole, incorporating biochemical, physiological, and environment interactions. Systems medicine draws on systems science and systems biology, and considers complex interactions within the human body in light of a patient's genomics, behavior and environment.[1]

The earliest uses of the term systems medicine appeared in 1992, in an article on systems medicine and pharmacology by B.J. Zeng [2] and in a paper on systems biomedicine by T. Kamada.[3]

An important topic in systems medicine and systems biomedicine is the development of computational models that describe disease progression and the effect of therapeutic interventions. [4] [5]

More recent approaches include the redefinition of disease phenotypes based on common mechanisms rather than symptoms. These provide then therapeutic targets including network pharmacology[6] and drug repurposing[7]. Since 2018, there is a dedicated scientific journal, Systems Medicine, published by Marie-Ann Liebert and with Jan Baumbach and Harald Schmidt as co-editors in chief.[8]

List of systems (bio)medicine research groups[edit]

Country University / Institute Department / Center / Program / Network Participants
Ireland Royal College of Surgeons in Ireland Medical Systems Biology[9]
Luxembourg Luxembourg Centre for Systems Biomedicine Computational Biology group[10]
Netherlands Eindhoven University of Technology (TU/e) Department of Biomedical Engineering, Computational Biology Group (CBio)[11] Natal van Riel, Peter Hilbers
USA Institute for Systems Biology (ISB) Leroy Hood, Alan Aderem, Ruedi Aebersold
Germany Helmholtz Association of German Research Centres

Universitätsklinikum Schleswig-Holstein

Department of Systems Immunology[12]Institute of Experimental Medicine Esteban Hernandez-Vargas

Dr. Christoph Kaleta

Netherlands Utrecht University

University Medical Center Utrecht

Maastricht University

Laboratory of Translational Immunology[13]

Utrecht Center for Quantitative Immunology[14]

Pharmacology and Personalised Medicine[15]

Prof. Timothy Radstake,

Dr. Aridaman Pandit

Prof. Harald H.H.W. Schmidt

References[edit]

  1. ^ Federoff, Howard; Gostin, Lawrence O. (2009). "Evolving from Reductionism to Holism: Is There a Future for Systems Medicine?". Journal of the American Medical Association. 302 (9): 994–996. doi:10.1001/jama.2009.1264. PMID 19724047.
  2. ^ Zeng (B.) J., On the holographic model of human body, 1st National Conference of Comparative Studies Traditional Chinese Medicine and West Medicine, Medicine and Philosophy, April, 1992 ( termed "systems medicine and pharmacology").
  3. ^ Kamada T. ,System biomedicine: a new paradigm in biomedical engineering. Front Med Biol Eng. 1992;4(1):1-2.
  4. ^ de Winter W, DeJongh J, Post T, Ploeger B, Urquhart R, Moules I, Eckland D, Danhof M. A mechanism-based disease progression model for comparison of long-term effects of pioglitazone, metformin and gliclazide on disease processes underlying Type 2 Diabetes Mellitus. J Pharmacokinet Pharmacodyn. 2006 Jun;33(3):313-43.
  5. ^ Tiemann, CA; Vanlier, J; Oosterveer, MH; Groen, AK; Hilbers, PA; van Riel, NA (Aug 2013). "Parameter trajectory analysis to identify treatment effects of pharmacological interventions". PLoS Comput. Biol. 9 (8): e1003166. doi:10.1371/journal.pcbi.1003166.
  6. ^ Oettrich, Jm; Dao, Vt; Frijhoff, J; Kleikers, Pwm; Casas, Ai; Hobbs, Aj; Schmidt, Hhhw (2016-04-01). "Clinical relevance of cyclic GMP modulators: A translational success story of network pharmacology". Clinical Pharmacology & Therapeutics. 99 (4): 360–362. doi:10.1002/cpt.336. ISSN 1532-6535.
  7. ^ Langhauser, Friederike; Casas, Ana I.; Dao, Vu-Thao-Vi; Guney, Emre; Menche, Jörg; Geuss, Eva; Kleikers, Pamela W. M.; López, Manuela G.; Barabási, Albert-L. (2018-02-05). "A diseasome cluster-based drug repurposing of soluble guanylate cyclase activators from smooth muscle relaxation to direct neuroprotection". npj Systems Biology and Applications. 4 (1). doi:10.1038/s41540-017-0039-7. ISSN 2056-7189.
  8. ^ Baumbach, Jan; Schmidt, Harald H.H.W. (2018). "The End of Medicine as We Know It: Introduction to the New Journal, Systems Medicine". Systems Medicine. 1: 1–2. doi:10.1089/sysm.2017.28999.jba.
  9. ^ Royal College of Surgeons in Ireland, Medical Systems Biology
  10. ^ Computational Biology group, LCSB
  11. ^ Computational Biology Group, Eindhoven University of Technology
  12. ^ http://www.helmholtz-hzi.de/en/research/research_topics/immune_response/systems_immunology/team/personal/infos/esteban_vargas/
  13. ^ http://www.umcutrecht.nl/nl/Ziekenhuis/Zorgverleners/Radstake-TRDJ
  14. ^ http://theory.bio.uu.nl/ucqi/
  15. ^ "Pharmacology & Personalised Medicine | Pharmacology & Personalised Medicine". ppm.mumc.maastrichtuniversity.nl. Retrieved 2017-02-02.