T-cell surface glycoprotein CD3 epsilon chain

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CD3E
Protein CD3E PDB 1xiw.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CD3E, IMD18, T3E, TCRE, CD3e molecule
External IDs MGI: 88332 HomoloGene: 586 GeneCards: 916
RNA expression pattern
PBB GE CD3E 205456 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000733

NM_007648

RefSeq (protein)

NP_000724.1

NP_031674.1

Location (UCSC) Chr 11: 118.3 – 118.32 Mb Chr 9: 45 – 45.01 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

CD3e molecule, epsilon also known as CD3E is a polypeptide which in humans is encoded by the CD3E gene which resides on chromosome 11.[1][2]

Function[edit]

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development.[3]

Clinical significance[edit]

Defects in this gene cause severe immunodeficiency.[4][5] This gene has also been linked to a susceptibility to type I diabetes in women.[6]

Interactions[edit]

T-cell surface glycoprotein CD3 epsilon chain has been shown to interact with TOP2B,[7] CD3EAP[8] and NCK2.[9]

See also[edit]

References[edit]

  1. ^ Gold DP, Puck JM, Pettey CL, Cho M, Coligan J, Woody JN, Terhorst C (1986). "Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex". Nature 321 (6068): 431–4. doi:10.1038/321431a0. PMID 3012357. 
  2. ^ Clevers HC, Dunlap S, Wileman TE, Terhorst C (November 1988). "Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter". Proc. Natl. Acad. Sci. U.S.A. 85 (21): 8156–60. doi:10.1073/pnas.85.21.8156. PMC 282386. PMID 3267235. 
  3. ^ "Entrez Gene: CD3E CD3e molecule, epsilon (CD3-TCR complex)". 
  4. ^ Soudais C, de Villartay JP, Le Deist F, Fischer A, Lisowska-Grospierre B (January 1993). "Independent mutations of the human CD3-epsilon gene resulting in a T cell receptor/CD3 complex immunodeficiency". Nat. Genet. 3 (1): 77–81. doi:10.1038/ng0193-77. PMID 8490660. 
  5. ^ de Saint Basile G, Geissmann F, Flori E, Uring-Lambert B, Soudais C, Cavazzana-Calvo M, Durandy A, Jabado N, Fischer A, Le Deist F (November 2004). "Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3". J. Clin. Invest. 114 (10): 1512–7. doi:10.1172/JCI22588. PMC 525745. PMID 15546002. 
  6. ^ Wong S, Moore S, Orisio S, Millward A, Demaine AG (January 1991). "Susceptibility to type I diabetes in women is associated with the CD3 epsilon locus on chromosome 11". Clin. Exp. Immunol. 83 (1): 69–73. doi:10.1111/j.1365-2249.1991.tb05590.x. PMC 1535466. PMID 1671006. 
  7. ^ Nakano, H; Yamazaki T; Miyatake S; Nozaki N; Kikuchi A; Saito T (Mar 1996). "Specific interaction of topoisomerase II beta and the CD3 epsilon chain of the T cell receptor complex". J. Biol. Chem. (UNITED STATES) 271 (11): 6483–9. doi:10.1074/jbc.271.11.6483. ISSN 0021-9258. PMID 8626450. 
  8. ^ Yamazaki, T; Hamano Y; Tashiro H; Itoh K; Nakano H; Miyatake S; Saito T (Jun 1999). "CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells". J. Biol. Chem. (UNITED STATES) 274 (26): 18173–80. doi:10.1074/jbc.274.26.18173. ISSN 0021-9258. PMID 10373416. 
  9. ^ Gil, Diana; Schamel Wolfgang W A, Montoya María, Sánchez-Madrid Francisco, Alarcón Balbino (Jun 2002). "Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation". Cell (United States) 109 (7): 901–12. doi:10.1016/S0092-8674(02)00799-7. ISSN 0092-8674. PMID 12110186.  Cite uses deprecated parameter |coauthors= (help)

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.